INT190361

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Context Info
Confidence 0.97
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 3.01
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (PPARA) nucleoplasm (PPARA) small molecule metabolic process (PPARA)
nucleus (PPARA) DNA binding (PPARA) lipid metabolic process (PPARA)
PPARA (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 224 99.84 Very High Very High Very High
antagonist 28 99.76 Very High Very High Very High
Potency 3 99.52 Very High Very High Very High
Inflammatory response 22 92.16 High High
Inflammation 102 67.84 Quite High
tolerance 2 56.80 Quite High
chemokine 1 13.52 Low Low
Spinal cord 1 13.20 Low Low
Bile 26 5.00 Very Low Very Low Very Low
cINOD 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 27 100.00 Very High Very High Very High
INFLAMMATION 127 92.16 High High
Cancer 307 91.60 High High
Disease 38 89.92 High High
Lipodystrophy 3 85.04 High High
Breast Cancer 19 84.96 Quite High
Starvation 1 79.64 Quite High
Death 40 79.60 Quite High
Diabetes Mellitus 49 78.92 Quite High
Glioma 2 78.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
has been suggested to promote the degradation of the PPAR?
Protein_catabolism (degradation) of PPAR
1) Confidence 0.97 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.09 Pain Relevance 0.12
pathways can influence the degradation process of PPAR?
Protein_catabolism (degradation) of PPAR
2) Confidence 0.67 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.43 Pain Relevance 0
Additionally, expression of numerous acyl-CoA synthetases is induced by PPAR?
Protein_catabolism (by) of PPAR
3) Confidence 0.64 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.06 Pain Relevance 0.05
on both lipid and glucose metabolism was highlighted in transgenic mice overexpressing PPAR?
Protein_catabolism (highlighted) of PPAR associated with targeted disruption
4) Confidence 0.55 Published 2010 Journal PPAR Research Section Body Doc Link PMC2933910 Disease Relevance 0.51 Pain Relevance 0.14
The activation of Tusc5 gene expression by both agents, and the fact that the magnitude of EC50 differences match the known potency of these molecules for binding and activating PPAR?
Protein_catabolism (binding) of PPAR associated with potency
5) Confidence 0.52 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.06 Pain Relevance 0.20
promoting its degradation, the detailed mechanisms by which PPAR?
Protein_catabolism (degradation) of PPAR
6) Confidence 0.49 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 0.77 Pain Relevance 0.21
Increased proteolysis might reduce PPAR levels and produce apparently
Protein_catabolism (proteolysis) of PPAR
7) Confidence 0.28 Published 2008 Journal PPAR Research Section Body Doc Link PMC2423003 Disease Relevance 0.23 Pain Relevance 0.07
degradation, activation of PPAR?
Protein_catabolism (degradation) of PPAR
8) Confidence 0.28 Published 2008 Journal PPAR Research Section Body Doc Link PMC2423003 Disease Relevance 0.22 Pain Relevance 0.03
degradation of PPAR?
Protein_catabolism (degradation) of PPAR
9) Confidence 0.28 Published 2008 Journal PPAR Research Section Body Doc Link PMC2423003 Disease Relevance 0 Pain Relevance 0
activation is associated with dedifferentiation and/or COX-2 expression and PGE2 production. 15d-PGJ2-induced inhibition of type II collagen and SOX-9 expression was prevented by the addition of 10 ┬ÁM BADGE (bisphenol A diglycidyl ether, PPAR-?
Protein_catabolism (diglycidyl) of PPAR
10) Confidence 0.24 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693859 Disease Relevance 0 Pain Relevance 0.05
2821T and Ala12) function remains uncertain, taken together these findings suggest that Ala12 may alter PPAR?
Protein_catabolism (alter) of PPAR
11) Confidence 0.21 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.17 Pain Relevance 0
transcriptional activity and reduced the stability of the PPAR?
Protein_catabolism (stability) of PPAR
12) Confidence 0.17 Published 2006 Journal BMC Med Genet Section Body Doc Link PMC1368963 Disease Relevance 0.17 Pain Relevance 0
proteasomal degradation of ligand-activated PPAR?
Protein_catabolism (degradation) of PPAR
13) Confidence 0.14 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528242 Disease Relevance 0.29 Pain Relevance 0

General Comments

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