INT190362

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.19
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (PPARA) nucleoplasm (PPARA) small molecule metabolic process (PPARA)
nucleus (PPARA) DNA binding (PPARA) lipid metabolic process (PPARA)
Anatomy Link Frequency
plasma 2
liver 2
PPARA (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 36 99.84 Very High Very High Very High
ischemia 11 97.24 Very High Very High Very High
COX-2 inhibitor 3 54.72 Quite High
Inflammation 25 5.00 Very Low Very Low Very Low
Bile 9 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 85 99.60 Very High Very High Very High
Hypoxia 15 99.16 Very High Very High Very High
Cv Unclassified Under Development 7 97.24 Very High Very High Very High
Repression 3 95.96 Very High Very High Very High
Adhesions 1 95.80 Very High Very High Very High
Acute Coronary Syndrome 1 95.52 Very High Very High Very High
Targeted Disruption 6 93.68 High High
Prostate Cancer 15 84.72 Quite High
Lung Cancer 7 84.60 Quite High
Disease 62 77.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
activation impairs post-ischemic cardiac function in experimental models of DM, we tested whether decreased PPARA transcription in PPARA A carriers favorably impacted outcome after acute coronary ischemia in 705 patients hospitalized with acute coronary syndromes (ACS; 552 Caucasian, 106 African American).
Spec (whether) Negative_regulation (decreased) of Transcription (transcription) of PPARA associated with acute coronary syndrome, diabetes mellitus and ischemia
1) Confidence 0.42 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2933242 Disease Relevance 0.92 Pain Relevance 0.12
demonstrated to reduce the mRNA levels of PPAR-?
Negative_regulation (reduce) of Transcription (levels) of PPAR
2) Confidence 0.31 Published 2008 Journal PPAR Research Section Body Doc Link PMC2366048 Disease Relevance 1.14 Pain Relevance 0
In Klaassen's study, the mRNA levels of several SULTs were suppressed in female mouse liver following PPAR?
Negative_regulation (suppressed) of Transcription (following) of PPAR in liver
3) Confidence 0.30 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0 Pain Relevance 0.20
to repress gene transcription of specific PPAR?
Negative_regulation (repress) of Transcription (transcription) of PPAR
4) Confidence 0.22 Published 2008 Journal PPAR Research Section Body Doc Link PMC2605846 Disease Relevance 0.63 Pain Relevance 0.10
molecular targets, since C-681G and C-689T were associated with increased plasma LDL levels and A-14G with a decreased activity of PPAR?
Negative_regulation (decreased) of Transcription (activity) of PPAR in plasma
5) Confidence 0.12 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.51 Pain Relevance 0
This was confirmed by further mixing experiments in which an increasing amount of mutant or WT receptor was mixed with a fixed amount of WT PPAR?
Negative_regulation (fixed) of Transcription (amount) of PPAR
6) Confidence 0.11 Published 2006 Journal BMC Med Genet Section Body Doc Link PMC1368963 Disease Relevance 0 Pain Relevance 0

General Comments

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