INT190363

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Context Info
Confidence 0.44
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 4.80
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (PPARA) nucleoplasm (PPARA) small molecule metabolic process (PPARA)
nucleus (PPARA) DNA binding (PPARA) lipid metabolic process (PPARA)
PPARA (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 61 100.00 Very High Very High Very High
Inflammatory mediators 12 98.72 Very High Very High Very High
Inflammation 115 97.60 Very High Very High Very High
Osteoarthritis 130 92.80 High High
Inflammatory stimuli 2 82.24 Quite High
Multiple sclerosis 85 67.20 Quite High
Endocannabinoid 4 64.28 Quite High
cINOD 11 58.60 Quite High
cytokine 29 45.04 Quite Low
aspirin 5 21.60 Low Low
Disease Link Frequency Relevance Heat
Obesity 68 99.32 Very High Very High Very High
INFLAMMATION 139 98.72 Very High Very High Very High
Cancer 201 97.44 Very High Very High Very High
Apoptosis 89 94.32 High High
Disease 83 93.24 High High
Osteoarthritis 132 92.80 High High
Lipodystrophy 3 88.36 High High
Colon Cancer 9 86.80 High High
Non-small-cell Lung Cancer 38 81.52 Quite High
Colorectal Cancer 23 80.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
this interaction induces activation rather than inhibition of PPAR-?
Positive_regulation (induces) of Negative_regulation (inhibition) of PPAR
1) Confidence 0.44 Published 2007 Journal PPAR Research Section Body Doc Link PMC2220082 Disease Relevance 0.71 Pain Relevance 0
this interaction induces activation rather than inhibition of PPAR-?
Positive_regulation (activation) of Negative_regulation (inhibition) of PPAR
2) Confidence 0.44 Published 2007 Journal PPAR Research Section Body Doc Link PMC2220082 Disease Relevance 0.71 Pain Relevance 0
1/2 leads to attenuation of PPAR?
Positive_regulation (leads) of Negative_regulation (attenuation) of PPAR
3) Confidence 0.43 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 0.06 Pain Relevance 0
, it is reasonable to speculate that the suppression of PPAR?
Positive_regulation (speculate) of Negative_regulation (suppression) of PPAR
4) Confidence 0.36 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 1.05 Pain Relevance 0.35
B activation participates in the IL-1-mediated downregulation of PPAR?
Positive_regulation (participates) of Negative_regulation (downregulation) of PPAR
5) Confidence 0.36 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.42 Pain Relevance 0.18
Several studies have described increased or decreased levels of PPAR?
Positive_regulation (increased) of Negative_regulation (decreased) of PPAR
6) Confidence 0.20 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.62 Pain Relevance 0
The therapeutic potential of agonists of PPAR, such as rosiglitazone (Avandia™) and pioglitazone (Actos™) for PPAR?
Positive_regulation (potential) of Negative_regulation (agonists) of PPAR associated with agonist
7) Confidence 0.18 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2829540 Disease Relevance 0.37 Pain Relevance 0.34
treatment induces a rapid reduction of PPAR?
Positive_regulation (induces) of Negative_regulation (reduction) of PPAR
8) Confidence 0.17 Published 2008 Journal PPAR Research Section Body Doc Link PMC2423003 Disease Relevance 0.25 Pain Relevance 0
The Y355X mutation caused the complete inactivation of PPAR?
Positive_regulation (caused) of Negative_regulation (inactivation) of PPAR
9) Confidence 0.12 Published 2006 Journal BMC Med Genet Section Body Doc Link PMC1368963 Disease Relevance 0.18 Pain Relevance 0
2 mutation, Pro115Gln, highlighted the relevance of phosphorylation at Ser 114 in reducing PPAR?
Positive_regulation (highlighted) of Negative_regulation (reducing) of PPAR
10) Confidence 0.12 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.43 Pain Relevance 0

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