INT190387

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 3.95
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (DEFB4A)
Anatomy Link Frequency
epithelial cells 2
middle ear 1
DEFB4A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 122 99.48 Very High Very High Very High
psoriasis 100 99.44 Very High Very High Very High
Inflammation 49 82.40 Quite High
rheumatoid arthritis 20 70.80 Quite High
chemokine 8 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Inflammatory stimuli 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 79 100.00 Very High Very High Very High
Hemophilus Infection 240 99.86 Very High Very High Very High
Psoriasis 138 99.44 Very High Very High Very High
Otitis Media 30 87.04 High High
INFLAMMATION 58 82.40 Quite High
Rheumatoid Arthritis 20 70.80 Quite High
Skin Diseases 10 32.16 Quite Low
Eczema 38 6.00 Low Low
Blister 9 5.00 Very Low Very Low Very Low
Infection 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is obvious from figure 4 that the clinical severity in psoriasis patients is a far stronger determinant of hBD-2 serum concentration than copy number for uninduced levels in healthy controls (figure 3).
Spec (determinant) Regulation (determinant) of hBD-2 associated with psoriasis
1) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0.91 Pain Relevance 0.35
Middle ear epithelial cells released IL-1 alpha when stimulated by NTHi components and this cytokine acted in an autocrine/paracrine synergistic manner with NTHi to up-regulate beta-defensin 2.
Regulation (regulate) of beta-defensin 2 in epithelial cells associated with hemophilus infection and cytokine
2) Confidence 0.27 Published 2006 Journal BMC Infect Dis Section Abstract Doc Link PMC1368979 Disease Relevance 0.66 Pain Relevance 0.20
Synergistic effect of interleukin 1 alpha on nontypeable Haemophilus influenzae-induced up-regulation of human beta-defensin 2 in middle ear epithelial cells

Background

Regulation (regulation) of beta-defensin 2 in middle ear associated with hemophilus infection
3) Confidence 0.27 Published 2006 Journal BMC Infect Dis Section Title Doc Link PMC1368979 Disease Relevance 0.57 Pain Relevance 0.10
Based on these observations, we investigated if human middle ear epithelial cells could release IL-1 alpha upon exposure to a lysate of NTHi and if this cytokine could have a synergistic effect on beta-defensin 2 up-regulation by the bacterial components.


Regulation (effect) of beta-defensin 2 in epithelial cells associated with hemophilus infection and cytokine
4) Confidence 0.27 Published 2006 Journal BMC Infect Dis Section Abstract Doc Link PMC1368979 Disease Relevance 0.59 Pain Relevance 0.13
There were insufficient numbers of informative psoriasis patients from whom defensin copy numbers and PASI scores were available, to make a reliable estimate of the effect of copy number and disease severity on hBD-2 levels.
Regulation (effect) of hBD-2 associated with psoriasis and disease
5) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 1.23 Pain Relevance 0.47

General Comments

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