INT190388

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Context Info
Confidence 0.52
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.92
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (DEFB4A)
Anatomy Link Frequency
epithelial cells 2
DEFB4A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 56 75.28 Quite High
Inflammation 14 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Inflammatory stimuli 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hemophilus Infection 160 98.78 Very High Very High Very High
Otitis Media 20 57.60 Quite High
INFLAMMATION 20 5.00 Very Low Very Low Very Low
Blister 6 5.00 Very Low Very Low Very Low
Autolysis 4 5.00 Very Low Very Low Very Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Confusion 4 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Hearing Impairment 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We recently showed that beta-defensins have antimicrobial activity against nontypeable Haemophilus influenzae (NTHi) and that interleukin 1 alpha (IL-1 alpha) up-regulates the transcription of beta-defensin 2 (DEFB4 according to new nomenclature of the Human Genome Organization) in human middle ear epithelial cells via a Src-dependent Raf-MEK1/2-ERK signaling pathway.
Transcription (transcription) of beta-defensin 2 in epithelial cells associated with hemophilus infection
1) Confidence 0.52 Published 2006 Journal BMC Infect Dis Section Abstract Doc Link PMC1368979 Disease Relevance 0.46 Pain Relevance 0.06
We recently showed that beta-defensins have antimicrobial activity against nontypeable Haemophilus influenzae (NTHi) and that interleukin 1 alpha (IL-1 alpha) up-regulates the transcription of beta-defensin 2 (DEFB4 according to new nomenclature of the Human Genome Organization) in human middle ear epithelial cells via a Src-dependent Raf-MEK1/2-ERK signaling pathway.
Transcription (transcription) of DEFB4 in epithelial cells associated with hemophilus infection
2) Confidence 0.52 Published 2006 Journal BMC Infect Dis Section Abstract Doc Link PMC1368979 Disease Relevance 0.46 Pain Relevance 0.09

General Comments

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