INT190389

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Context Info
Confidence 0.44
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.58
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK1) mitochondrion (MAPK1) Golgi apparatus (MAPK1)
DNA binding (MAPK1) protein complex (MAPK1) response to stress (MAPK1)
Anatomy Link Frequency
eosinophil 2
MAPK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 38 79.04 Quite High
fibrosis 8 59.28 Quite High
Inflammation 17 5.00 Very Low Very Low Very Low
Crohn's disease 10 5.00 Very Low Very Low Very Low
Nerve growth factor 8 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Eosinophilic Esophagitis 212 98.48 Very High Very High Very High
Hemophilus Infection 80 93.36 High High
Hypersensitivity 8 92.00 High High
Disease 37 88.12 High High
Cicatrix 2 67.72 Quite High
Fibrosis 12 59.28 Quite High
Dysphagia 6 57.00 Quite High
Injury 4 50.52 Quite High
Eosinophilia 2 37.76 Quite Low
Gastroesophageal Reflux Disease 72 35.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
bFGF expression is essential to the transcription of ERK [18] and ERK feeds into the eotaxin-3 pathway, potentially further activating the eosinophil and improving its sensitivity and migration towards eotaxin in the esophageal tissue.
Transcription (transcription) of ERK in eosinophil
1) Confidence 0.44 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 0.98 Pain Relevance 0.06
bFGF expression is essential to the transcription of ERK [18] and ERK feeds into the eotaxin-3 pathway, potentially further activating the eosinophil and improving its sensitivity and migration towards eotaxin in the esophageal tissue.
Transcription (transcription) of ERK in eosinophil
2) Confidence 0.33 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 0.98 Pain Relevance 0.06
-defensin 2 transcription via the ERK pathway, the synergistic up-regulation of ?
Transcription (transcription) of ERK
3) Confidence 0.10 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1368979 Disease Relevance 0.61 Pain Relevance 0.04

General Comments

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