INT190418

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Context Info
Confidence 0.49
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 4.71
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neuronal 1
hair 1
B-cell 1
nucleus 1
AAVS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Rheumatism 2 97.48 Very High Very High Very High
Chronic pancreatitis 5 92.16 High High
intrathecal 70 91.84 High High
cytokine 21 91.00 High High
glial activation 2 88.32 High High
tolerance 2 84.52 Quite High
rheumatoid arthritis 8 71.16 Quite High
spinal inflammation 2 68.60 Quite High
Lasting pain 8 67.64 Quite High
Arthritis 2 67.64 Quite High
Disease Link Frequency Relevance Heat
Vasculitis 120 100.00 Very High Very High Very High
Rheumatic Diseases 2 97.48 Very High Very High Very High
Toxicity 40 96.24 Very High Very High Very High
Recurrence 60 93.76 High High
Disease 112 93.44 High High
Pancreatitis 5 92.16 High High
Systemic Lupus Erythematosus 14 88.76 High High
Autoimmune Disease 21 84.52 Quite High
Nephritis 2 78.64 Quite High
Cardiomyopathy 26 78.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although Ad5 can enhance AAV2 transduction by stimulating AAV2 DNA second-strand synthesis [24,27], Ad5 capsids also facilitate translocation of AAV2 into the nucleus [28].
Positive_regulation (stimulating) of AAV in nucleus
1) Confidence 0.49 Published 2009 Journal Virol J Section Body Doc Link PMC2687429 Disease Relevance 0.16 Pain Relevance 0.09
All the AAV used for gene therapy studies are transcapsidated: that is to package an AAV genome containing an ITR from one serotype (AAV2) into the capsid of another serotype (i.e.
Positive_regulation (package) of AAV
2) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2660610 Disease Relevance 0.59 Pain Relevance 0
Increasing the Ad5 MOI to 10 significantly enhanced AAV2/8 transduction of rat islets.
Positive_regulation (enhanced) of AAV
3) Confidence 0.49 Published 2009 Journal Virol J Section Body Doc Link PMC2687429 Disease Relevance 0.17 Pain Relevance 0.09
AAV2/8 also did not transduce rat islets very well at this MOI (Figs. 3E–F), but significant transduction was achieved with AAV2/5 (Figs. 3C–D), suggesting that the requirement for Ad5 helper functions for AAV2/5 is less than that of AAV2/8.
Positive_regulation (requirement) of AAV
4) Confidence 0.49 Published 2009 Journal Virol J Section Body Doc Link PMC2687429 Disease Relevance 0 Pain Relevance 0
The primary receptors required for transduction for some of these AAV serotypes have been identified (such as sialic acid for AAV4 and AAV5 (Kaludov et al 2001; Walters et al 2001), including the sialo-glycoprotein PDGF-R (Di Pasquale et al 2003)) and can thus be associated with the transduction pattern for the relevant AAV.
Positive_regulation (some) of AAV
5) Confidence 0.20 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676804 Disease Relevance 0 Pain Relevance 0
This palindromic sequence is the only cis-acting element required for all the major functions of AAV (viral DNA replication, assembly of the viral particles, integration/excision from the host genome) and is the only sequence of viral origin present in the vector DNA.
Positive_regulation (required) of AAV
6) Confidence 0.20 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676804 Disease Relevance 0.12 Pain Relevance 0.03
region of the forward terminal repeat of AAV results in generation of an AAV containing both complementary strands [21,22].
Positive_regulation (generation) of AAV
7) Confidence 0.17 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2793898 Disease Relevance 0.24 Pain Relevance 0
AAV vector doses can also be increased to ?
Positive_regulation (increased) of AAV
8) Confidence 0.15 Published 2006 Journal Mol Pain Section Body Doc Link PMC1373607 Disease Relevance 0.12 Pain Relevance 0.40
All the AAV used for gene therapy studies are transcapsidated: that is to package an AAV genome containing an ITR from one serotype (AAV2) into the capsid of another serotype (i.e.
Positive_regulation (package) of AAV
9) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2660610 Disease Relevance 0.58 Pain Relevance 0
In this study, we report a simple minimally invasive hair-dryer based topical vector-delivery technique that significantly increases AAV-mediated transgene delivery in the mouse stroma in vivo, without compromising typical corneal morphology or function.
Positive_regulation (increases) of AAV in hair
10) Confidence 0.07 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2997332 Disease Relevance 0.27 Pain Relevance 0
Neutrophils are another important source of BLyS.84 Serum levels of BLyS have been found to be elevated in SLE85 and AAV.86 A proliferation-inducing ligand (APRIL) is another member of the TNF family87 and a potent stimulator of B-cell maturation and differentiation.
Positive_regulation (elevated) of AAV in B-cell associated with vasculitis
11) Confidence 0.07 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2893757 Disease Relevance 0.81 Pain Relevance 0.17
Current approaches to treatment in induction and maintenance of AAV are well established (Table 3).98 The European League against Rheumatism (EULAR) guidelines for the management of small and medium vessel vasculitis have recently been published99 and the role of newer agents such as MMF is being defined by clinical trials.
Positive_regulation (maintenance) of AAV associated with rheumatism and vasculitis
12) Confidence 0.06 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2893757 Disease Relevance 1.44 Pain Relevance 0.19
We chose these two AAV serotypes because we have shown that these are the most efficient AAV serotype vectors for these two neuronal populations [26,27].
Positive_regulation (efficient) of AAV in neuronal
13) Confidence 0.04 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2841193 Disease Relevance 0.06 Pain Relevance 0
The AAV MOI was increased in this experiment over the MOIs in the other experiments, because these viruses were purified using CsCl density gradients while the other viruses had been purified using an iodixanol gradient followed by ion exchange or heparin chromatography.
Positive_regulation (increased) of AAV
14) Confidence 0.04 Published 2009 Journal Virol J Section Body Doc Link PMC2687429 Disease Relevance 0 Pain Relevance 0
However, increasing the AAV MOI to 1.0 × 104, while maintaining an Ad5 MOI of 10, did facilitate AAV2/8 transduction of rat islets (Fig. 2C).
Positive_regulation (increasing) of AAV
15) Confidence 0.04 Published 2009 Journal Virol J Section Body Doc Link PMC2687429 Disease Relevance 0.06 Pain Relevance 0

General Comments

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