INT19044

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Context Info
Confidence 0.65
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 7.70
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (GGT5) plasma membrane (GGT5) transferase activity, transferring acyl groups (GGT5)
cellular amino acid metabolic process (GGT5)
Anatomy Link Frequency
leucocytes 2
liver 1
platelets 1
GGT5 (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 7 99.36 Very High Very High Very High
Inflammation 21 99.12 Very High Very High Very High
headache 1 98.04 Very High Very High Very High
adenocard 2 96.00 Very High Very High Very High
cva 1 88.08 High High
eye pain 1 88.04 High High
cINOD 2 83.92 Quite High
Bile 4 82.76 Quite High
Central nervous system 2 82.56 Quite High
pruritus 1 81.00 Quite High
Disease Link Frequency Relevance Heat
Stress 7 100.00 Very High Very High Very High
Syndrome 2 99.96 Very High Very High Very High
Favism 1 99.68 Very High Very High Very High
Abdominal Pain 7 99.36 Very High Very High Very High
INFLAMMATION 24 99.12 Very High Very High Very High
Hemangioma 2 98.78 Very High Very High Very High
Convulsion 1 98.70 Very High Very High Very High
Lymphopenia 1 98.64 Very High Very High Very High
Coma 1 98.38 Very High Very High Very High
Leukocytosis 1 98.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At the same time, platelets were at lower level during the first 8 days and gamma-glutamyltransferase (gamma-GT), a marker of oxidative stress, was significantly increased.
Positive_regulation (increased) of gamma-glutamyltransferase in platelets associated with stress
1) Confidence 0.65 Published 2007 Journal Burns Section Abstract Doc Link 17532574 Disease Relevance 0.53 Pain Relevance 0.09
Fepradinol and indometacin prevented the carrageenin-induced inflammation in rats: they acted on the exudate, on the increase of protein and gamma-glutamyltransferase levels, and also reduced the number of leucocytes.
Positive_regulation (increase) of gamma-glutamyltransferase in leucocytes associated with inflammation
2) Confidence 0.65 Published 1994 Journal Arzneimittelforschung Section Abstract Doc Link 7907874 Disease Relevance 0.71 Pain Relevance 0.26
Hepatobiliary involvement was reported 25 times, including increases in alkaline phosphatase, gamma-glutamyltransferase, and alanine and aspartate aminotransferase levels.
Positive_regulation (creases i) of gamma-glutamyltransferase
3) Confidence 0.06 Published 2006 Journal Drug Saf Section Abstract Doc Link 17061910 Disease Relevance 1.59 Pain Relevance 0.14
Reported adverse effects of bitter melon include hypoglycemic coma and convulsions in children, reduced fertility in mice, a favism-like syndrome, increases in gamma-glutamyltransferase and alkaline phosphatase levels in animals, and headaches.
Positive_regulation (increases) of gamma-glutamyltransferase associated with convulsion, syndrome, favism, headache and coma
4) Confidence 0.04 Published 2003 Journal Am J Health Syst Pharm Section Abstract Doc Link 12625217 Disease Relevance 0.57 Pain Relevance 0.10
In conclusion, we report the cases of two patients with large hemangiomas of the liver, abdominal pain, increased ESR and fibrinogen, increased serum alkaline phosphatase and gamma-glutamyltransferase activity, and normal white blood cell counts.
Positive_regulation (increased) of gamma-glutamyltransferase in liver associated with abdominal pain and hemangioma
5) Confidence 0.03 Published 1991 Journal Dig. Dis. Sci. Section Abstract Doc Link 2007371 Disease Relevance 0.60 Pain Relevance 0.17
Na(+), K(+)-ATPase activity was decreased, whereas those of 5'-nucleotidase, Mg(2+)-ATPase, and gamma-glutamyltransferase increased.
Positive_regulation (increased) of gamma-glutamyltransferase
6) Confidence 0.02 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10411591 Disease Relevance 0.20 Pain Relevance 0.07
Gallic acid treatment significantly attenuated some alterations (i.e. increased levels of aspartate transaminase, alanine transaminase, alkaline phosphatase, acid phosphatase, lactate dehydrogenase, gamma-glutamyltransferase, 5'-nucleotidase, bilirubin, alpha-fetoprotein, carcinoembryonic antigen) and decreased the levels of argyophillic nucleolar organizing regions (AgNORs) and proliferating cell nuclear antigen (PCNA) [90].
Positive_regulation (increased) of gamma-glutamyltransferase
7) Confidence 0.01 Published 2010 Journal J Transl Med Section Body Doc Link PMC2991329 Disease Relevance 0.06 Pain Relevance 0
Abnormal liver parameters (transient increases in alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma-glutamyltransferase) and white blood cell disorders (lymphopenia, leukocytosis and anemia) were regularly observed.
Positive_regulation (increases) of gamma-glutamyltransferase in white blood cell associated with anaemia, lymphopenia and leukocytosis
8) Confidence 0.01 Published 2010 Journal International Journal of Cancer. Journal International du Cancer Section Body Doc Link PMC2958458 Disease Relevance 1.40 Pain Relevance 0.14
Much greater changes were found in the kidneys, with increased activity of glucose-6-phosphate dehydrogenase and decreased activities of aspartate and alanine aminotransferases, alkaline phosphatase, malic dehydrogenase, sorbitol dehydrogenase and gamma-glutamyltransferase, as well as a decreased phosphorylation to oxidation ratio in the mitochondria, indicating reduced adenosine triphosphate production.
Positive_regulation (activity) of gamma-glutamyltransferase associated with adenocard
9) Confidence 0.01 Published 1994 Journal Eur J Clin Chem Clin Biochem Section Abstract Doc Link 7888481 Disease Relevance 0.14 Pain Relevance 0.10
Gastrointestinal tract involvement is limited, but elevations of gamma-glutamyltransferase levels are frequently noticed [11,15].
Positive_regulation (elevations) of gamma-glutamyltransferase
10) Confidence 0.01 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 1.89 Pain Relevance 0.04

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