INT190446

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Context Info
Confidence 0.10
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 0.89
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NR2E3) signal transduction (NR2E3) nucleus (NR2E3)
Anatomy Link Frequency
germ line 1
primordial germ cells 1
NR2E3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcium channel 3 20.32 Low Low
Spinal cord 4 5.64 Low Low
cytokine 10 5.00 Very Low Very Low Very Low
withdrawal 10 5.00 Very Low Very Low Very Low
cva 6 5.00 Very Low Very Low Very Low
Peripheral nerve injury 6 5.00 Very Low Very Low Very Low
dexamethasone 6 5.00 Very Low Very Low Very Low
Dismenorea 5 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Potency 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 62 97.64 Very High Very High Very High
Leukemia 3 95.52 Very High Very High Very High
Targeted Disruption 8 89.96 High High
Cancer 4 75.12 Quite High
Retina Disease 17 73.96 Quite High
Stomach Cancer 1 68.56 Quite High
Obesity 6 62.92 Quite High
Leber Congenital Amaurosis /

Leber Congenital Amaurosis

5 61.04 Quite High
Retinal Diseases 11 14.92 Low Low
Age-related Macular Degeneration 64 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
1 expression at the mRNA and protein levels in mouse ESCs.
Gene_expression (expression) of ESCs
1) Confidence 0.10 Published 2010 Journal Eplasty Section Body Doc Link PMC2885864 Disease Relevance 0.07 Pain Relevance 0
In primary ESCs we demonstrated incubation of cells with TGF?
Gene_expression (demonstrated) of ESCs
2) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0
Targeted knockdown of SMAD 4 in decidualized ESCs using two independent siRNAs (n?
Gene_expression (decidualized) of ESCs
3) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0
Targeted knockdown of SMAD 4 in decidualized ESCs using two independent siRNAs (n?
Gene_expression (using) of ESCs
4) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0
In primary ESCs we demonstrated incubation of cells with TGF?
Gene_expression (primary) of ESCs
5) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0
1 antibodies maintained expression of PRL mRNA (Figure 2A) and significantly potentiated expression of IGFBP-1 mRNA in comparison with ESCs treated with DM alone (p<0.001, Figure 2B).


Gene_expression (expression) of ESCs
6) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0
Alkaline phosphatase is an enzyme long-known to be expressed in ESCs as well as primordial germ cells [37].
Gene_expression (expressed) of ESCs in primordial germ cells
7) Confidence 0.05 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1373634 Disease Relevance 0.14 Pain Relevance 0
Sox-2 is a regulatory transcription factor expressed in early development in many tissues including ESCs [6].
Gene_expression (expressed) of ESCs
8) Confidence 0.04 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1373634 Disease Relevance 0.19 Pain Relevance 0
To advance animal biotechnology, it will be necessary to produce ESCs and EGCs that display germ line transmission in species other than the mouse; so far this has not met with success [22].
Gene_expression (produce) of ESCs in germ line
9) Confidence 0.04 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1373634 Disease Relevance 0.16 Pain Relevance 0
It is therefore possible that RNR were introduced later on (from viruses??)
Gene_expression (introduced) of RNR
10) Confidence 0.04 Published 2008 Journal Biol Direct Section Body Doc Link PMC2478661 Disease Relevance 0 Pain Relevance 0
Similarly, protocols for RPE production from ESCs are being refined, and functional studies on human ESC-derived RPE demonstrate their physiological viability [162].
Gene_expression (production) of ESCs
11) Confidence 0.01 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962903 Disease Relevance 0.22 Pain Relevance 0

General Comments

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