INT19047

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Context Info
Confidence 0.73
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.73
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SLC25A4) generation of precursor metabolites and energy (SLC25A4) mitochondrion (SLC25A4)
small molecule metabolic process (SLC25A4) enzyme binding (SLC25A4) transmembrane transport (SLC25A4)
Anatomy Link Frequency
proximal 2
lateral 1
SLC25A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 4 100.00 Very High Very High Very High
antagonist 2 99.86 Very High Very High Very High
Potency 2 99.48 Very High Very High Very High
Pain 3 97.76 Very High Very High Very High
adenocard 2 75.00 Quite High
peripheral neuropathy 16 70.32 Quite High
Inflammation 4 65.96 Quite High
neuralgia 1 55.36 Quite High
addiction 2 45.56 Quite Low
Electroencephalography 2 29.60 Quite Low
Disease Link Frequency Relevance Heat
Prolapse 1 99.84 Very High Very High Very High
Disease 82 99.62 Very High Very High Very High
Pain 1 97.76 Very High Very High Very High
Facioscapulohumeral Muscular Dystrophy 150 94.84 High High
Eye Disease 2 86.08 High High
Paralysis 1 79.92 Quite High
Syndrome 12 79.20 Quite High
Liver Failure 2 74.48 Quite High
Epilepsy 2 72.88 Quite High
Ataxia 22 70.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The relative inhibitory potency of GHRH-Antagonist (GHRH-Ant) to GHRH(1-44)NH2 and mechanism of L-dopa- or clonidine-induced GH release were studied in seven normal subjects using GHRH-Ant.
Localization (release) of Ant associated with antagonist, clonidine and potency
1) Confidence 0.73 Published 1996 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8626863 Disease Relevance 0 Pain Relevance 0.31
A case of lateral prolapse of the T-1/T-2 intervertebral disk is presented.
Localization (presented) of T-1 in lateral associated with prolapse
2) Confidence 0.68 Published 1991 Journal Surg Neurol Section Abstract Doc Link 2008650 Disease Relevance 0.28 Pain Relevance 0.15
The furthest proximal sequence that is considered a disease candidate gene is SLC25A4 (ANT1), which is located on 4q35.1 ?
Localization (located) of ANT1 in proximal associated with disease
3) Confidence 0.68 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2794184 Disease Relevance 0.72 Pain Relevance 0
The furthest proximal sequence that is considered a disease candidate gene is SLC25A4 (ANT1), which is located on 4q35.1 ?
Localization (located) of SLC25A4 in proximal associated with disease
4) Confidence 0.68 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2794184 Disease Relevance 0.72 Pain Relevance 0
Visual failure was a prominent feature of their phenotypes and when initial screens for POLG1, POLG2, PEO1 and SLC25A4 were found to be negative, OPA1 sequencing was performed.
Localization (screens) of SLC25A4
5) Confidence 0.67 Published 2010 Journal Brain Section Body Doc Link PMC2842512 Disease Relevance 0.37 Pain Relevance 0.03
Over the past decade, a growing number of nuclear genetic defects have been identified that disrupt mitochondrial function either by a reduction in mtDNA copy number, and/or the accumulation of secondary mtDNA deletions: POLG1, POLG2, PEO1, SLC25A4, TYMP, DGUOK, TK2, SUCLA2, SUCLG1, MPV17 and RRM2B (Hudson and Chinnery, 2006; Chinnery and Zeviani, 2008; Copeland, 2008).
Localization (accumulation) of SLC25A4
6) Confidence 0.67 Published 2010 Journal Brain Section Body Doc Link PMC2842512 Disease Relevance 0.64 Pain Relevance 0.07

General Comments

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