INT190471

Context Info Confidence 0.21 First Reported 2006 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.76 Pain Relevance 0

extracellular space (ENG) cell motility (ENG) cell adhesion (ENG) nucleolus (ENG) nucleus (ENG) cytoplasm (ENG)

ENG (Homo sapiens)

Pain Link Frequency Relevance Heat Opioid 20 5.00 tolerance 11 5.00 Hyperalgesia 11 5.00 IPN 10 5.00 Inflammation 9 5.00 opioid receptor 9 5.00 Pain 8 5.00 antinociception 5 5.00 Enkephalin 5 5.00 Endogenous opioid 4 5.00

Disease Link Frequency Relevance Heat Syndrome 38 96.92 Polyps 35 92.52 Hyperplasia 15 68.72 Hantavirus Infection 7 66.08 Cancer 31 50.16 Diabetes Mellitus 69 50.00 Colorectal Cancer 50 50.00 Hamartoma 3 47.44 Proteus Syndrome 1 46.80 Cytomegalovirus Infection 1 14.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Mutations have been described in the SMAD4, BMPR1A and ENG genes.

Transcription (described) of ENG

1) Confidence 0.21 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 1.76 Pain Relevance 0

b) The ACTH fragment was removed, the original END sequence was preserved and the MSH fragment was replaced with an additional sequence of END.

Transcription (preserved) of END

2) Confidence 0.11 Published 2009 Journal Mol Pain Section Body Doc Link PMC2797781 Disease Relevance 0 Pain Relevance 0

Several newspaper ads were placed, especially at the beginning and end of the recruitment period.

Transcription (beginning) of end

3) Confidence 0.05 Published 2006 Journal BMC Public Health Section Body Doc Link PMC1373687 Disease Relevance 0 Pain Relevance 0

General Comments

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