INT190479

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Context Info
Confidence 0.07
First Reported 2006
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.64
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (1190002H23Rik) nucleus (1190002H23Rik) cell cycle (1190002H23Rik)
cytoplasm (1190002H23Rik)
Anatomy Link Frequency
apoptotic cell 1
ganglion cell 1
optic nerve 1
RGC 1
1190002H23Rik (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 20 99.98 Very High Very High Very High
withdrawal 2 98.88 Very High Very High Very High
Glutamate 8 98.26 Very High Very High Very High
Inflammation 36 95.48 Very High Very High Very High
cytokine 4 66.84 Quite High
Inflammatory mediators 2 5.60 Low Low
anesthesia 18 5.00 Very Low Very Low Very Low
isoflurane 9 5.00 Very Low Very Low Very Low
imagery 7 5.00 Very Low Very Low Very Low
ketamine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 85 100.00 Very High Very High Very High
Apoptosis 37 99.98 Very High Very High Very High
Retina Disease 8 99.98 Very High Very High Very High
Drug Induced Neurotoxicity 10 99.70 Very High Very High Very High
Death 105 99.58 Very High Very High Very High
Optic Nerve Injuries 4 98.82 Very High Very High Very High
Glaucoma 92 98.80 Very High Very High Very High
INFLAMMATION 40 95.48 Very High Very High Very High
Stress 122 94.72 High High
Targeted Disruption 21 94.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The studies reported herein strongly suggest a role for PEDF in the maintenance of RGC in the DBA/2J mouse model of glaucoma, and add indirectly to the evidence for reduced PEDF as a possible pathogenic mechanism in human glaucoma.
Positive_regulation (maintenance) of RGC associated with glaucoma
1) Confidence 0.07 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 1.29 Pain Relevance 0.22
PEDF has also been shown to protect adult rat retinal ganglion cells (RGC) from glutamate- and trophic factor withdrawal-mediated cytotoxicity [7], and reduce retinal ischemia-induced RGC loss [8,9].
Positive_regulation (induced) of RGC in RGC associated with ganglion cysts, glutamate, ischemia, withdrawal and retina disease
2) Confidence 0.06 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 1.24 Pain Relevance 0.27
In both pigmented [13,37] and albino [38] rats, the STR diminishes significantly shortly after optic nerve transection, a diminution that correlates with the pattern of axotomy-induced RGC loss and persists for long periods of time without recovery, indicating that the integrity of the RGC population is needed to evoke a full STR in these rodents.
Positive_regulation (induced) of RGC in optic nerve associated with optic nerve injuries
3) Confidence 0.03 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 0.41 Pain Relevance 0
Propolis inhibited the neurotoxicity and apoptosis induced in cultured retinal ganglion cells (RGC-5, a rat ganglion cell line transformed using E1A virus) by 24 h H2O2 exposure.
Positive_regulation (induced) of RGC-5 in ganglion cell associated with ganglion cysts, drug induced neurotoxicity and apoptosis
4) Confidence 0.03 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Abstract Doc Link PMC1375228 Disease Relevance 0.72 Pain Relevance 0.04
On the other hand, we found that staurosporine, which mediates mitochondrial dysfunctions resulting in apoptotic cell death, did not induce any increases in BiP and CHOP proteins in RGC-5 [unpublished data].
Neg (not) Positive_regulation (increases) of RGC-5 in apoptotic cell associated with apoptosis and death
5) Confidence 0.03 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 1.17 Pain Relevance 0
RGC-5 damage was induced by tunicamycin, and cell viability was measured by double nuclear staining (Hoechst 33342 and either YO-PRO-1 or propidium iodide).
Positive_regulation (induced) of RGC-5
6) Confidence 0.03 Published 2007 Journal Molecular Vision Section Abstract Doc Link PMC2652022 Disease Relevance 0.82 Pain Relevance 0

General Comments

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