INT190480

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Context Info
Confidence 0.34
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 8.29
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ros1) cell proliferation (Ros1) signal transduction (Ros1)
plasma membrane (Ros1) kinase activity (Ros1)
Anatomy Link Frequency
cochlea 2
hepatocytes 2
cochlear 2
epithelial cells 2
lungs 2
Ros1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 111 100.00 Very High Very High Very High
qutenza 62 99.98 Very High Very High Very High
chemokine 23 99.84 Very High Very High Very High
depression 11 99.44 Very High Very High Very High
Inflammation 188 96.68 Very High Very High Very High
fibrosis 7 95.40 Very High Very High Very High
ischemia 9 93.12 High High
cva 3 90.52 High High
Nerve growth factor 1 84.72 Quite High
Dopamine 61 82.72 Quite High
Disease Link Frequency Relevance Heat
Stress 87 100.00 Very High Very High Very High
Shock 9 99.98 Very High Very High Very High
Hypoxia 4 99.98 Very High Very High Very High
Disease 138 99.58 Very High Very High Very High
Dermatitis 27 99.44 Very High Very High Very High
Depression 12 99.44 Very High Very High Very High
Hepatitis C Virus Infection 8 99.40 Very High Very High Very High
Hepatitis B Virus Infection 8 99.20 Very High Very High Very High
Noise-induced Hearing Loss 52 99.16 Very High Very High Very High
Asthma 2 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These considerations support the suggestion that the NIHL following exposure to broadband noise is due to excessive release of ROS which disrupts sensitive elements in the cochlea.
Positive_regulation (due) of Localization (release) of ROS in cochlea associated with noise-induced hearing loss
1) Confidence 0.34 Published 2010 Journal J Occup Med Toxicol Section Body Doc Link PMC2936911 Disease Relevance 0.34 Pain Relevance 0.08
Furosemide, producing a smaller metabolic demand as a result of the depression of the cochlear amplifier, leads to the release of lower levels of ROS, with less damage, whereas anti-oxidants counteract the elevated ROS levels induced by the noise exposure.
Positive_regulation (leads) of Localization (release) of ROS in cochlear associated with depression
2) Confidence 0.32 Published 2010 Journal J Occup Med Toxicol Section Body Doc Link PMC2936911 Disease Relevance 0.38 Pain Relevance 0.11
These data demonstrate that capsaicin initiates ROS generation through TRPV1 activation.
Positive_regulation (initiates) of Localization (generation) of ROS associated with qutenza
3) Confidence 0.23 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.06 Pain Relevance 0.45
Viral proteins including the HBV X and HCV core proteins are capable of inducing ROS accumulation in hepatocytes [73].
Positive_regulation (inducing) of Localization (accumulation) of ROS in hepatocytes associated with hepatitis b virus infection and hepatitis c virus infection
4) Confidence 0.09 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.26 Pain Relevance 0.11
Pretreatment of human bronchial epithelial cells with metal chelators and/or free radical scavengers reduces vanadium-generated ROS, MAPK activation, as well as release of chemokines, further supporting a role for oxidative stress in vanadium-induced inflammation [62].
Positive_regulation (generated) of Localization (release) of ROS in epithelial cells associated with stress, chemokine and inflammation
5) Confidence 0.06 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2861012 Disease Relevance 1.00 Pain Relevance 0.45
Briefly, staurosporine rapidly increased the intracellular level of ROS, and N-acetyl-cystein (NAC), an antioxidant inhibited the production of ROS, activation of caspase-3 and cell death.
Positive_regulation (increased) of Localization (level) of ROS associated with death
6) Confidence 0.04 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1375228 Disease Relevance 0.92 Pain Relevance 0
is significantly augmented by antecedent shock; and this effect of shock is particularly mediated by shock-induced ROS released from PMN.
Positive_regulation (induced) of Localization (released) of ROS associated with shock
7) Confidence 0.04 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913855 Disease Relevance 0.67 Pain Relevance 0.05
Complex II dysfunction has been related to neurodegenerative diseases such as Huntington's disease, as well as hypoxia-dependent generation of ROS in lungs 30.
Positive_regulation (dependent) of Localization (generation) of ROS in lungs associated with hypoxia, disease and neurodegenerative disease
8) Confidence 0.04 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1925139 Disease Relevance 0.71 Pain Relevance 0.11
In this state, microglia are capable of upregulating the synthesis and release of a host of proinflammatory and prooxidant factors, including cytokines, prostaglandins (PGs) and reactive oxygen species (ROS) [26].
Positive_regulation (upregulating) of Localization (release) of ROS in microglia associated with cytokine
9) Confidence 0.03 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3018622 Disease Relevance 0.79 Pain Relevance 0.33
Once again, XO expression (as determined by electron spin resonance spectroscopy) and myocardial ROS generation were markedly increased in the post-mycardial infarction ischemic model.44 This suggests a role for allopurinol in LV remodeling, a possibility that we are investigating at present in our unit.
Positive_regulation (increased) of Localization (generation) of ROS associated with infarction
10) Confidence 0.03 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672460 Disease Relevance 0.78 Pain Relevance 0.05
Increased oxidative stress status, specially elevation of ROS, has been described in patients with AD.
Positive_regulation (Increased) of Localization (elevation) of ROS associated with stress and dermatitis
11) Confidence 0.02 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994734 Disease Relevance 1.39 Pain Relevance 0.08

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