INT190519

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Context Info
Confidence 0.32
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 14
Total Number 16
Disease Relevance 9.99
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ros1) cell proliferation (Ros1) signal transduction (Ros1)
plasma membrane (Ros1) kinase activity (Ros1)
Anatomy Link Frequency
cochlear 4
plasma 2
liver 2
Ros1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 147 99.90 Very High Very High Very High
depression 12 97.44 Very High Very High Very High
cytokine 92 95.44 Very High Very High Very High
agonist 35 83.68 Quite High
tolerance 49 81.68 Quite High
cINOD 1 78.16 Quite High
Nicotine 40 74.48 Quite High
fibrosis 20 67.60 Quite High
metalloproteinase 6 63.92 Quite High
Paracetamol 8 57.28 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 229 100.00 Very High Very High Very High
Stress 194 99.98 Very High Very High Very High
Vasculitis 1 99.90 Very High Very High Very High
Fatty Liver 71 98.98 Very High Very High Very High
Apoptosis 43 98.88 Very High Very High Very High
Cancer 110 98.84 Very High Very High Very High
Hepatocellular Cancer 99 98.84 Very High Very High Very High
Aging 16 98.40 Very High Very High Very High
Depression 12 97.44 Very High Very High Very High
Injury 117 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furosemide, producing a smaller metabolic demand as a result of the depression of the cochlear amplifier, leads to the release of lower levels of ROS, with less damage, whereas anti-oxidants counteract the elevated ROS levels induced by the noise exposure.
Positive_regulation (elevated) of Positive_regulation (induced) of ROS in cochlear associated with depression
1) Confidence 0.32 Published 2010 Journal J Occup Med Toxicol Section Body Doc Link PMC2936911 Disease Relevance 0.43 Pain Relevance 0.11
Furosemide, producing a smaller metabolic demand as a result of the depression of the cochlear amplifier, leads to the release of lower levels of ROS, with less damage, whereas anti-oxidants counteract the elevated ROS levels induced by the noise exposure.
Positive_regulation (induced) of Positive_regulation (elevated) of ROS in cochlear associated with depression
2) Confidence 0.32 Published 2010 Journal J Occup Med Toxicol Section Body Doc Link PMC2936911 Disease Relevance 0.43 Pain Relevance 0.11
The increased ROS levels in diabetes could be due to their increased production and/or decreased destruction by antioxidants such as GSH, SOD, catalase and glutathione peroxidase [17-21].
Positive_regulation (due) of Positive_regulation (increased) of ROS associated with diabetes mellitus
3) Confidence 0.18 Published 2010 Journal J Nanobiotechnology Section Body Doc Link PMC2914719 Disease Relevance 0.68 Pain Relevance 0
Estimation of ROS generation in the liver revealed that gold nanoparticles blocked the high glucose-induced increase in ROS generation to a maximum extent in the liver which is shown in Figure 5.
Positive_regulation (increase) of Positive_regulation (generation) of ROS in liver
4) Confidence 0.17 Published 2010 Journal J Nanobiotechnology Section Body Doc Link PMC2914719 Disease Relevance 1.03 Pain Relevance 0
were correlated with increased ROS accumulation, which led to JNK and STAT3 activation.
Positive_regulation (increased) of Positive_regulation (accumulation) of ROS
5) Confidence 0.12 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.21 Pain Relevance 0.07
Additionally, the generated ROS can serve as a second messenger molecule in mediating TNF-?
Positive_regulation (mediating) of Positive_regulation (generated) of ROS
6) Confidence 0.10 Published 2006 Journal BMC Clin Pathol Section Body Doc Link PMC1382240 Disease Relevance 0.94 Pain Relevance 0.27
These results suggest that increased ROS and ROS-mediated JNK activation is a critical regulator for HCC development (Figure 3).
Positive_regulation (increased) of Positive_regulation (activation) of ROS-mediated associated with hepatocellular cancer
7) Confidence 0.10 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.30 Pain Relevance 0.10
In the present study we could demonstrate that GTN treatment resulted in an increase in mitochondrial ROS and a decrease in ALDH-2 activity in the Mn-SOD+/- mice whereas PETN did not significantly alter these parameters (Figure 2 and Results).


Positive_regulation (resulted) of Positive_regulation (increase) of mitochondrial ROS
8) Confidence 0.09 Published 2006 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1654181 Disease Relevance 0.43 Pain Relevance 0.18
Increases in intracellular ROS can enhance activation of NF-?
Positive_regulation (enhance) of Positive_regulation (Increases) of ROS
9) Confidence 0.08 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2413210 Disease Relevance 0.23 Pain Relevance 0.15
This hypothesis is consistent with our findings that splenectomy strongly inhibited (i) the BDL-induced increase in ROS generation by the circulating neutrophils (Fig. 7), (ii) the elevation of plasma IFN-?
Positive_regulation (induced) of Positive_regulation (increase) of ROS in plasma
10) Confidence 0.07 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275763 Disease Relevance 0.54 Pain Relevance 0.19
It is unknown whether increased conversion of stearic acid to oleic acid observed in NAFLD increases uncoupling of the P450 catalytic cycle, resulting in increased ROS formation by SCD-1 sequestering cytochrome b5.
Spec (whether) Positive_regulation (resulting) of Positive_regulation (increased) of ROS associated with fatty liver
11) Confidence 0.04 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.40 Pain Relevance 0
Oxidative stress leads to the accelerated production and increased accumulation of reactive oxygen species (ROS),2 which contribute to both cancer and aging by causing oxidative damage to proteins and DNA (1).
Positive_regulation (increased) of Positive_regulation (accumulation) of ROS associated with stress, aging and cancer
12) Confidence 0.02 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0.30 Pain Relevance 0.06
Overexpression of CRIF1 enhanced both basal and H2O2-induced ROS accumulation, and CRIF1 knockdown reduced both basal and H2O2-induced ROS accumulation (Fig. 8, A and B).
Positive_regulation (induced) of Positive_regulation (accumulation) of ROS
13) Confidence 0.02 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0.22 Pain Relevance 0
Overexpression of CRIF1 enhanced both basal and H2O2-induced ROS accumulation, and CRIF1 knockdown reduced both basal and H2O2-induced ROS accumulation (Fig. 8, A and B).
Positive_regulation (induced) of Positive_regulation (accumulation) of ROS
14) Confidence 0.02 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0.23 Pain Relevance 0
Oxidative stress leads to the accelerated production and increased accumulation of reactive oxygen species (ROS),2 which contribute to both cancer and aging by causing oxidative damage to proteins and DNA (1).
Positive_regulation (leads) of Positive_regulation (accumulation) of ROS associated with stress, aging and cancer
15) Confidence 0.02 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0.30 Pain Relevance 0.06
Furthermore, AGE products promote vascular inflammation and induce ROS accumulation, and both of these processes contribute to endothelial dysfunction via inhibition of NO production.
Positive_regulation (induce) of Positive_regulation (accumulation) of ROS associated with inflammation and vasculitis
16) Confidence 0.02 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 1.31 Pain Relevance 0.21

General Comments

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