INT190522

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Context Info
Confidence 0.39
First Reported 2006
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.47
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Hmgb1) extracellular region (Hmgb1) cell morphogenesis (Hmgb1)
nucleolus (Hmgb1) chromosome (Hmgb1) nucleus (Hmgb1)
Hmgb1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 24 99.82 Very High Very High Very High
Nicotine 40 93.28 High High
cytokine 76 91.48 High High
Inflammation 44 91.12 High High
Hippocampus 13 78.60 Quite High
chemokine 17 72.08 Quite High
Inflammatory response 10 62.56 Quite High
ischemia 20 50.00 Quite Low
vagus nerve 6 22.16 Low Low
Neurotransmitter 2 21.40 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 61 91.12 High High
Sepsis 12 89.20 High High
Injury 74 87.08 High High
Rheumatoid Arthritis 1 85.04 High High
Cognitive Disorder 37 83.08 Quite High
Disease 3 78.56 Quite High
Death 3 63.04 Quite High
Cv Unclassified Under Development 20 50.00 Quite Low
Reperfusion Injury 2 50.00 Quite Low
Necrosis 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, IL-1Ra treatment had no effects on HMGB-1 levels, which maintained a similar pattern to that seen after LPS injection in the absence of IL-1Ra (Figure 2c).
Neg (no) Regulation (effects) of Gene_expression (levels) of HMGB-1
1) Confidence 0.39 Published 2010 Journal Crit Care Section Body Doc Link PMC2911722 Disease Relevance 0.29 Pain Relevance 0.30
Whether the cholinergic agonists had any effect on HMGB-1 production in the study presented here remains unclear.
Spec (Whether) Regulation (effect) of Gene_expression (production) of HMGB-1 associated with agonist
2) Confidence 0.37 Published 2006 Journal BMC Clin Pathol Section Body Doc Link PMC1382240 Disease Relevance 1.19 Pain Relevance 0.47

General Comments

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