INT190524

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Context Info
Confidence 0.02
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 4.24
Pain Relevance 2.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ros1, Nfkb1) cell differentiation (Ros1) mitochondrion (Nfkb1)
DNA binding (Nfkb1) protein complex (Nfkb1) cytoplasm (Nfkb1)
Anatomy Link Frequency
monocytes 1
neurons 1
oligodendrocytes 1
microglial cells 1
Ros1 (Mus musculus)
Nfkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 6 99.70 Very High Very High Very High
chemokine 16 99.44 Very High Very High Very High
Nicotine 40 98.30 Very High Very High Very High
Inflammation 161 96.64 Very High Very High Very High
Inflammatory response 8 96.32 Very High Very High Very High
cytokine 66 96.12 Very High Very High Very High
metalloproteinase 1 92.68 High High
agonist 33 81.00 Quite High
Inflammatory mediators 15 78.60 Quite High
cINOD 82 64.80 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 200 99.54 Very High Very High Very High
Atherosclerosis 7 99.20 Very High Very High Very High
Drug Induced Neurotoxicity 30 97.16 Very High Very High Very High
Parkinson's Disease 324 95.96 Very High Very High Very High
Apoptosis 5 95.00 High High
Death 10 94.80 High High
Stress 5 77.56 Quite High
Injury 89 76.40 Quite High
Aging 54 60.96 Quite High
Disease 109 57.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Iho et al. showed that nicotine induces human neutrophils to produce IL-8 (CXC chemokine) through the production of ROS and subsequent activation of NF-kB, with no effect on monocytes [43].
ROS Positive_regulation (activation) of NF-kB in monocytes associated with chemokine and nicotine
1) Confidence 0.02 Published 2006 Journal BMC Clin Pathol Section Body Doc Link PMC1382240 Disease Relevance 0.51 Pain Relevance 0.45
In addition, ROS can activate the transcription factor NF-kB, that is ubiquitously expressed and mediates the expression of genes involved in the acute inflammatory response, including the cytokines IL1-IL6 and IL8 [23], which in turn modulate CRP production.
ROS Positive_regulation (activate) of NF-kB associated with inflammatory response and cytokine
2) Confidence 0.02 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2987999 Disease Relevance 0.54 Pain Relevance 0.23
Inflammatory stimuli together with ROS and RNS activate nuclear factor-kB (NF-kB) in microglial cells, oligodendrocytes and neurons to promote the transcription of inflammatory cytokines, COX-2, iNOS, and apoptosis-promoting factor including p53/Bax [see [45,46]].
ROS Positive_regulation (activate) of NF-kB in microglial cells associated with inflammation, apoptosis, cytokine and inflammatory stimuli
3) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 1.06 Pain Relevance 0.46
Inflammatory stimuli together with ROS and RNS activate nuclear factor-kB (NF-kB) in microglial cells, oligodendrocytes and neurons to promote the transcription of inflammatory cytokines, COX-2, iNOS, and apoptosis-promoting factor including p53/Bax [see [45,46]].
ROS Positive_regulation (activate) of NF-kB in neurons associated with inflammation, apoptosis, cytokine and inflammatory stimuli
4) Confidence 0.00 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 1.06 Pain Relevance 0.46
Inflammatory stimuli together with ROS and RNS activate nuclear factor-kB (NF-kB) in microglial cells, oligodendrocytes and neurons to promote the transcription of inflammatory cytokines, COX-2, iNOS, and apoptosis-promoting factor including p53/Bax [see [45,46]].
ROS Positive_regulation (activate) of NF-kB in oligodendrocytes associated with inflammation, apoptosis, cytokine and inflammatory stimuli
5) Confidence 0.00 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 1.06 Pain Relevance 0.46

General Comments

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