INT190571

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Context Info
Confidence 0.35
First Reported 2006
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 1.64
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

translation (Eef2) GTPase activity (Eef2) cytoplasm (Eef2)
Anatomy Link Frequency
neuronal 2
bladder 1
Eef2 (Mus musculus)
Pain Link Frequency Relevance Heat
member 8 36 100.00 Very High Very High Very High
Inflammation 102 54.96 Quite High
cerebral cortex 30 30.40 Quite Low
Inflammatory response 8 26.44 Quite Low
Neuropeptide 12 5.00 Very Low Very Low Very Low
cocaine 6 5.00 Very Low Very Low Very Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
interstitial cystitis 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Overactive Bladder 122 99.16 Very High Very High Very High
Obesity 60 98.16 Very High Very High Very High
Stress 18 91.68 High High
Targeted Disruption 6 89.12 High High
Polycystic Kidney Disease 2 84.64 Quite High
Disease 24 76.00 Quite High
Death 28 67.68 Quite High
Apoptosis 46 58.80 Quite High
INFLAMMATION 114 54.96 Quite High
Increased Venous Pressure Under Development 2 5.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Survival related gene, Voltage dependent anion channel (Vdac1) and ubiquitin related gene, ubiquitin B (Ubb) and genes involved in localized neuronal translation, cytoplasmic beta-actin (Actb), eukaryotic elongation factor2 (Eef2) and eukaryotic elongation factor 1 (Eef1alpha 1); retrograde transport, p25 subunit of dynactin (Dctn5), were amongst the genes that showed significant upregulation in 59Q transfected cells as compared to internally normalized expression levels in vector transfected controls (Fig. 1).
Gene_expression (expression) of Eef2 in neuronal
1) Confidence 0.35 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.29 Pain Relevance 0
Survival related gene, Voltage dependent anion channel (Vdac1) and ubiquitin related gene, ubiquitin B (Ubb) and genes involved in localized neuronal translation, cytoplasmic beta-actin (Actb), eukaryotic elongation factor2 (Eef2) and eukaryotic elongation factor 1 (Eef1alpha 1); retrograde transport, p25 subunit of dynactin (Dctn5), were amongst the genes that showed significant upregulation in 59Q transfected cells as compared to internally normalized expression levels in vector transfected controls (Fig. 1).
Gene_expression (expression) of elongation factor2 in neuronal
2) Confidence 0.31 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.35 Pain Relevance 0
On the other hand, the housekeeping genes eEF-2, ribosomal protein L37 and L38, proteasome (prosome, macropain) 26 subunit non-ATPase 4, eIF3, hypothetical protein, LRC member 8 also known as interleukin-8 receptor (IL-8R), and the RIKEN cDNA C030036P15, 1500016L11 and 2410104I19 genes are constantly expressed in all the tissues investigated.
Gene_expression (expressed) of eEF-2 associated with member 8
3) Confidence 0.27 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1888706 Disease Relevance 0.08 Pain Relevance 0.18
Remarkably, eukaryotic translation elongation factor 2 (eEF-2) was highly and constantly expressed in all the investigated tissues.
Gene_expression (expressed) of eEF-2
4) Confidence 0.27 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1888706 Disease Relevance 0.17 Pain Relevance 0.09
Remarkably, eukaryotic translation elongation factor 2 (eEF-2) was highly and constantly expressed in all the investigated tissues.
Gene_expression (expressed) of eukaryotic translation elongation factor 2
5) Confidence 0.27 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1888706 Disease Relevance 0.18 Pain Relevance 0.09
Here, we identified constantly expressed housekeeping genes, such as eukaryotic translation elongation factor 2, which is expressed in all tissues without significant difference in expression levels.
Gene_expression (expressed) of eukaryotic translation elongation factor 2
6) Confidence 0.21 Published 2007 Journal BMC Genomics Section Abstract Doc Link PMC1888706 Disease Relevance 0 Pain Relevance 0
Here, we identified constantly expressed housekeeping genes, such as eukaryotic translation elongation factor 2, which is expressed in all tissues without significant difference in expression levels.
Gene_expression (expression) of eukaryotic translation elongation factor 2
7) Confidence 0.21 Published 2007 Journal BMC Genomics Section Abstract Doc Link PMC1888706 Disease Relevance 0 Pain Relevance 0
Here, we identified constantly expressed housekeeping genes, such as eukaryotic translation elongation factor 2, which is expressed in all tissues without significant difference in expression levels.
Neg (without) Gene_expression (expressed) of eukaryotic translation elongation factor 2
8) Confidence 0.21 Published 2007 Journal BMC Genomics Section Abstract Doc Link PMC1888706 Disease Relevance 0 Pain Relevance 0
YY1, SF-1, and EF2 were found upstream of ambladder (RIKEN clone 9530014P05 or prothymosin alpha).
Gene_expression (found) of EF2
9) Confidence 0.01 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.27 Pain Relevance 0
The regulatory network for the control bladder mucosa (MC) was obtained in comparison to detrusor control and contained the following over-represented TREs: GA-binding protein (GABP), YY1 (yin yang 1), SF-1 (steroidogenic factor-1), EF2, CRE-BP1, and Sp-3 (trans-acting transcription factor 3).
Gene_expression (represented) of EF2 in bladder associated with overactive bladder
10) Confidence 0.01 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.31 Pain Relevance 0.08

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