INT19058

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Context Info
Confidence 0.70
First Reported 1981
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 2.03
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (RLN1) extracellular region (RLN1)
Anatomy Link Frequency
plasma 1
ligaments 1
thyroid 1
RLN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 2 99.96 Very High Very High Very High
backache 56 99.62 Very High Very High Very High
iatrogenic 2 98.52 Very High Very High Very High
Pain 54 97.76 Very High Very High Very High
pain pelvic 9 96.48 Very High Very High Very High
Inflammation 2 96.48 Very High Very High Very High
sSRI 1 95.12 Very High Very High Very High
antidepressant 1 92.00 High High
Dismenorea 2 89.36 High High
metalloproteinase 50 83.72 Quite High
Disease Link Frequency Relevance Heat
Low Back Pain 56 99.62 Very High Very High Very High
Injury 14 97.92 Very High Very High Very High
Pain 53 97.76 Very High Very High Very High
Thyroid Neoplasm 28 96.76 Very High Very High Very High
Reprotox - General 3 9 96.48 Very High Very High Very High
INFLAMMATION 2 96.48 Very High Very High Very High
Stress 2 94.12 High High
Dysmenorrhea 2 89.36 High High
Sperm Disorder 2 73.36 Quite High
Hyperemia 2 56.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is not yet possible to measure relaxin receptors in these women but high levels of relaxin or a susceptibility to relaxin may be contributing to this problem.
Positive_regulation (levels) of relaxin
1) Confidence 0.70 Published 1991 Journal Scand. J. Rheumatol. Suppl. Section Abstract Doc Link 2011710 Disease Relevance 0.07 Pain Relevance 0
For example, some studies have found back pain to correlate with increased levels of relaxin which are produced during pregnancy [17] even though others have not [18, 19].
Positive_regulation (increased) of relaxin associated with backache
2) Confidence 0.67 Published 2008 Journal Curr Rev Musculoskelet Med Section Body Doc Link PMC2684210 Disease Relevance 1.09 Pain Relevance 0.89
The present study was designed to evaluate whether serum relaxin concentrations were elevated in pregnant women with clear subjective and objective evidence of pain attributable to relaxation of the pelvic ligaments.
Spec (whether) Positive_regulation (elevated) of relaxin in ligaments associated with pain
3) Confidence 0.60 Published 1997 Journal Eur. J. Obstet. Gynecol. Reprod. Biol. Section Abstract Doc Link 9243195 Disease Relevance 0.27 Pain Relevance 0.27
It is not yet possible to measure relaxin receptors in these women but high levels of relaxin or a susceptibility to relaxin may be contributing to this problem.
Positive_regulation (levels) of relaxin
4) Confidence 0.50 Published 1991 Journal Scand. J. Rheumatol. Suppl. Section Abstract Doc Link 2011710 Disease Relevance 0.07 Pain Relevance 0
Potent CYP3A4 inhibitors such as ketoconazole can cause dangerous increases in plasma concentrations of the H-1 antagonist terfenadine.
Positive_regulation (increases) of H-1 in plasma associated with antagonist
5) Confidence 0.49 Published 1997 Journal J Clin Psychopharmacol Section Abstract Doc Link 9408807 Disease Relevance 0 Pain Relevance 0.14
Human relaxin was inactivated by the reducing agent dithiothreitol, indicating that disulfide bonds are essential to the biological activity of human placental relaxin.
Positive_regulation (inactivated) of relaxin
6) Confidence 0.44 Published 1981 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6778893 Disease Relevance 0.08 Pain Relevance 0.08
Relaxin, a hormone that is elevated during pregnancy, can suppress myometrial contractile activity.
Positive_regulation (elevated) of Relaxin
7) Confidence 0.37 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7653512 Disease Relevance 0.09 Pain Relevance 0.19
However, with the availability of IONM, the issues are whether this new technology could further enhance RLN preservation and reduce the risk of iatrogenic RLN injury in thyroid surgery or thyroid cancer surgery in particular.
Positive_regulation (enhance) of RLN in thyroid associated with iatrogenic, thyroid neoplasm and injury
8) Confidence 0.06 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2926682 Disease Relevance 0.36 Pain Relevance 0.05
-estradiol plus relaxin, the induction of collagenase-1 and stromelysin-1 by ?
Positive_regulation (induction) of relaxin
9) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064880 Disease Relevance 0 Pain Relevance 0.11

General Comments

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