INT190591

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.52
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Rest) nucleus (Rest) intracellular (Rest)
DNA binding (Rest) protein complex (Rest) transcription factor binding (Rest)
Anatomy Link Frequency
neuronal 1
neuron 1
nucleus 1
Rest (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 2 97.24 Very High Very High Very High
opioid receptor 5 96.88 Very High Very High Very High
nav1.8 1 95.28 Very High Very High Very High
c fibre 1 94.00 High High
Neuropathic pain 2 92.92 High High
Pain 14 82.48 Quite High
cINOD 1 76.84 Quite High
monoamine 2 72.76 Quite High
GABAergic 2 70.80 Quite High
Inflammation 50 69.28 Quite High
Disease Link Frequency Relevance Heat
Disease 8 98.94 Very High Very High Very High
Repression 14 98.52 Very High Very High Very High
Overactive Bladder 61 98.20 Very High Very High Very High
Ganglion Cysts 2 97.24 Very High Very High Very High
Neuropathic Pain 3 92.92 High High
Cancer 10 90.92 High High
Prostate Cancer 1 88.64 High High
Nociception 18 84.80 Quite High
Pain 27 82.48 Quite High
Attention Deficit Hyperactivity Disorder 2 78.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In Huntington's disease, it has been proposed that mutant huntingtin led to accumulate the NRSF in nucleus, resulting in the strong repression of the BDNF which is controlled by NRSE (39).
Positive_regulation (accumulate) of NRSF in nucleus associated with repression and disease
1) Confidence 0.37 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0.75 Pain Relevance 0.03
Recently, it was proposed that activation of the rest/nrsf target genes overrides muscle differentiation pathways and converted myoblasts to a physiologically active neuronal phenotype [102].
Positive_regulation (activation) of nrsf in neuronal
2) Confidence 0.30 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.94 Pain Relevance 0.11
Upregulated neuron-restrictive silencer factor may then suppress expression of the ?
Positive_regulation (Upregulated) of neuron-restrictive silencer factor in neuron
3) Confidence 0.11 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942827 Disease Relevance 0.84 Pain Relevance 0.79

General Comments

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