INT190598

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Context Info
Confidence 0.25
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.60
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr1h2) DNA binding (Nr1h2) cytoplasm (Nr1h2)
Anatomy Link Frequency
CAR 1
finger 1
Nr1h2 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 2 87.40 High High
Inflammation 101 86.68 High High
metalloproteinase 2 79.48 Quite High
Inflammatory stimuli 3 70.52 Quite High
agonist 9 15.52 Low Low
cINOD 2 12.96 Low Low
Inflammatory response 8 6.84 Low Low
Bile 39 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
Crohn's disease 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 2 87.40 High High
INFLAMMATION 108 86.68 High High
Targeted Disruption 21 84.44 Quite High
Overactive Bladder 122 76.52 Quite High
Alzheimer's Dementia 2 72.72 Quite High
Breast Cancer 10 69.72 Quite High
Infection 6 68.04 Quite High
Inflammatory Bowel Disease 32 67.76 Quite High
Leukemia 4 66.72 Quite High
Apoptosis 15 62.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several TREs upstream of actg 2 and my19 were over-represented in MIDI, including LXR which was described above, SRF, COUP, Pax-9, CP2, and RFX1.
Localization (represented) of LXR
1) Confidence 0.25 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.49 Pain Relevance 0.06
In terms of unique transcripts isolated from the MIDI library, our results indicate that transcripts such as zfp364 (zinc finger protein 364, also known as rab7) and sir2 are downstream of series of TFs including: USF, LXR, DEAF1, MAZ, and Lmo2 complex (figure 4).
Localization (series) of LXR in finger
2) Confidence 0.11 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.60 Pain Relevance 0.17
B and other nuclear receptors, since RXR is a common partner for many nuclear receptors including CAR, VDR, RAR, TR, LXR and PPARs [Xie and Tian, 2006].
Localization (receptors) of LXR in CAR
3) Confidence 0.10 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.50 Pain Relevance 0.13

General Comments

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