INT190619

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Context Info
Confidence 0.14
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.41
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (F2rl2) plasma membrane (F2rl2) signal transducer activity (F2rl2)
F2rl2 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 23 97.92 Very High Very High Very High
cytokine 10 92.68 High High
Inflammation 49 90.00 High High
cva 1 81.36 Quite High
ischemia 2 75.88 Quite High
Mechanotransduction 4 64.52 Quite High
Inflammatory mediators 3 60.80 Quite High
Arthritis 1 58.92 Quite High
metalloproteinase 2 51.00 Quite High
addiction 2 27.88 Quite Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 64 99.10 Very High Very High Very High
Reprotox - General 1 1 99.08 Very High Very High Very High
Atherosclerosis 1 98.88 Very High Very High Very High
Injury 57 98.48 Very High Very High Very High
Metastasis 1 98.28 Very High Very High Very High
Stress 45 93.76 High High
Hypertrophy 3 90.96 High High
INFLAMMATION 59 90.00 High High
Penetrating Head Injuries 5 87.16 High High
Cv General 3 Under Development 1 81.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The induced levels of the protease-activated receptor, PAR-1, were significantly attenuated in IL-1R1-null mice.
Positive_regulation (induced) of protease-activated receptor
1) Confidence 0.14 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.89 Pain Relevance 0.17
At least as attractive, and not mutually exclusive is the hypothesis that arterial injury, like in early atherosclerosis, will up-regulate endothelial expression of proteinase-activated-receptor 2 [53], which will be activated proteolytically within the atherosclerotic lesion and via systemic proteases to specifically sensitize endothelial TRPV4 channels to respond to mechanical stress [34].


Positive_regulation (activated) of proteinase-activated-receptor 2 associated with stress, atherosclerosis, injury and increased venous pressure under development
2) Confidence 0.13 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1959246 Disease Relevance 1.14 Pain Relevance 0.16
Once activated, the serine protease domain of tmprss2 is released from the cell surface into the extracellular space and activates PAR (protease-activated receptor)-2 that has a role in prostate cancer and tumor metastasis [70].
Positive_regulation (activates) of protease-activated receptor associated with metastasis and reprotox - general 1
3) Confidence 0.07 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.37 Pain Relevance 0.08

General Comments

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