INT190662

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Context Info
Confidence 0.24
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.15
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Prnp) endoplasmic reticulum (Prnp) nucleolus (Prnp)
plasma membrane (Prnp) nucleus (Prnp) cytoplasm (Prnp)
Anatomy Link Frequency
striatum 3
skin 2
cerebral cortex 1
Prnp (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 4 96.28 Very High Very High Very High
Hippocampus 6 96.20 Very High Very High Very High
Substantia nigra 2 95.68 Very High Very High Very High
Peripheral nervous system 3 95.00 High High
Thalamus 4 94.96 High High
medulla 8 55.24 Quite High
Central nervous system 4 29.28 Quite Low
Spinal cord 3 22.84 Low Low
agonist 10 5.92 Low Low
Clonidine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 98 83.72 Quite High
Scrapie 109 77.76 Quite High
Creutzfeldt Jakob Disease 73 73.64 Quite High
Sprains And Strains 114 63.60 Quite High
Infection 51 59.52 Quite High
Gliosis 2 10.24 Low Low
Hypertension 6 8.48 Low Low
Prion Diseases 33 5.00 Very Low Very Low Very Low
Targeted Disruption 21 5.00 Very Low Very Low Very Low
Chronic Wasting Disease 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, MM2 sCJD was characterized by a stronger PrPSc accumulation in the septum, lateral habenular nuclei, and hypothalamus, with only sparse labeling in the cerebral cortex and striatum.
Regulation (stronger) of Positive_regulation (accumulation) of PrPSc in striatum associated with cerebral cortex
1) Confidence 0.24 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1383487 Disease Relevance 0.33 Pain Relevance 0.33
In the same set of experiments we followed by Western blot analysis the level of total PrPC in non-infected MovS6 cells to determine if GA has any effect on the basal level of PrP expression in MovS6 cells, which could indirectly affect PrPSc accumulation (Figure 2 panel b, bottom).
Regulation (affect) of Positive_regulation (accumulation) of PrPSc
2) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291559 Disease Relevance 0 Pain Relevance 0
These studies were performed in order to (i) investigate whether anatomical structures within the skin may provide a target for PrPSc accumulation, (ii) elucidate the identity of such skin components, and (iii) find out whether prions can be present in the skin prior to the onset of visible TSE symptoms.
Regulation (target) of Positive_regulation (accumulation) of PrPSc in skin
3) Confidence 0.21 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1876502 Disease Relevance 0.50 Pain Relevance 0.05
On the other hand, MM2 sCJD was characterized by a stronger PrPSc accumulation in the septum, lateral habenular nuclei, and hypothalamus, with only sparse labeling in the cerebral cortex and striatum.
Regulation (stronger) of in cerebral cortex Positive_regulation (accumulation) of PrPSc in striatum associated with cerebral cortex
4) Confidence 0.08 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1383487 Disease Relevance 0.33 Pain Relevance 0.33

General Comments

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