INT190666

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.87
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Prnp) endoplasmic reticulum (Prnp) nucleolus (Prnp)
plasma membrane (Prnp) nucleus (Prnp) cytoplasm (Prnp)
Prnp (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 10 5.00 Very Low Very Low Very Low
cerebral cortex 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Thalamus 3 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Substantia nigra 1 5.00 Very Low Very Low Very Low
Eae 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 5 99.32 Very High Very High Very High
Targeted Disruption 38 95.92 Very High Very High Very High
Sprains And Strains 97 93.24 High High
Creutzfeldt Jakob Disease 60 92.92 High High
Disease 49 90.88 High High
Scrapie 79 80.80 Quite High
Infection 13 65.44 Quite High
Prion Diseases 14 26.64 Quite Low
Chronic Wasting Disease 1 19.44 Low Low
Ataxia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found PrPmyc to be fully functional and substitute dosage-dependently for endogenous PrP in rescuing the neurodegenerative phenotype induced by PrP?
Positive_regulation (dependently) of PrP Binding (endogenous) of associated with neurodegenerative disease
1) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635968 Disease Relevance 0.45 Pain Relevance 0
A putative cofactor, designated protein X, is thought to be required for PrPSc formation and may be involved in the experiments here [43].
Positive_regulation (required) of PrPSc Binding (formation) of
2) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2982847 Disease Relevance 0.50 Pain Relevance 0
It is, however, possible that mechanisms other than the PrP primary sequence contribute to the species barrier, for instance binding of PrPC [45] or PrPSc [46,47] to other proteins or to cellular factors.
Spec (possible) Positive_regulation (contribute) of PrPSc Binding (binding) of
3) Confidence 0.24 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1383487 Disease Relevance 0.92 Pain Relevance 0

General Comments

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