INT190675

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Context Info
Confidence 0.56
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 0.68
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nfatc1) DNA binding (Nfatc1) cytoplasm (Nfatc1)
Anatomy Link Frequency
NFAT 3
nucleus 2
HSF 1
Nfatc1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 40 90.64 High High
cytokine 134 88.88 High High
unmyelinated 4 81.56 Quite High
Nerve growth factor 17 78.20 Quite High
Inflammation 165 67.68 Quite High
nav1.8 2 66.28 Quite High
c fibre 2 65.72 Quite High
Central nervous system 3 54.88 Quite High
Peripheral nervous system 4 50.96 Quite High
Demyelination 12 48.28 Quite Low
Disease Link Frequency Relevance Heat
Asthma 318 94.24 High High
Neuroblastoma 3 72.64 Quite High
INFLAMMATION 167 67.68 Quite High
Hypersensitivity 16 63.36 Quite High
Cancer 21 62.32 Quite High
Sprains And Strains 2 62.28 Quite High
Bacterial Respiratory Disease 1 62.24 Quite High
Demyelinating Disease 14 48.28 Quite Low
Eczema 8 42.88 Quite Low
Targeted Disruption 25 41.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NFATc1 is dephosphorylated upon activation by calcineurin in the cell cytoplasm and then translocated to the nucleus.
Phosphorylation (dephosphorylated) of NFATc1 in nucleus
1) Confidence 0.56 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0 Pain Relevance 0.08
Unlike the IL-2 inhibitors, cyclosporin A and FK506, the BTPs do not directly inhibit the dephosphorylation of NFAT by calcineurin.
Phosphorylation (dephosphorylation) of NFAT
2) Confidence 0.25 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.29 Pain Relevance 0.16
Lack of calcineurin B prevents neuregulin-induced dephosphorylation and activation of NFAT c3 and c4.
Phosphorylation (dephosphorylation) of NFAT in NFAT
3) Confidence 0.12 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948355 Disease Relevance 0 Pain Relevance 0.03
This activates the phosphatase calcineurin, which dephosphorylates nuclear factor of activated T cells (NFAT) c3 and c4, resulting in translocation to the nucleus.
Phosphorylation (dephosphorylates) of NFAT in nucleus
4) Confidence 0.12 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948355 Disease Relevance 0 Pain Relevance 0.26
In contrast, p38 MAPK can inhibit NFAT transcriptional activity by phosphorylation of NFAT and by activation of NFAT nuclear export [73,74].
Phosphorylation (phosphorylation) of NFAT in NFAT
5) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.07 Pain Relevance 0.15
During antigen specific T-cell activation intracellular calcium is released and calcineurin is activated to dephosphorylate its target proteins including the transcription factor NFAT (nuclear factor of activated T cells).
Phosphorylation (dephosphorylate) of NFAT in T cells
6) Confidence 0.03 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1386691 Disease Relevance 0.06 Pain Relevance 0.04
phosphorylates several transcription factors, including AP-1, CREB, HSF-1, NFAT, C/EBP, and NF-kB [34], Ngn2 [55], and Smad3/4 [56].
Phosphorylation (phosphorylates) of NFAT in HSF
7) Confidence 0.02 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.26 Pain Relevance 0.04

General Comments

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