INT190677

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Context Info
Confidence 0.57
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 0.67
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nfatc1) DNA binding (Nfatc1) cytoplasm (Nfatc1)
Anatomy Link Frequency
osteoclast 2
nucleus 2
NFAT 1
Nfatc1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 62 96.64 Very High Very High Very High
cytokine 45 94.80 High High
Inflammation 152 74.88 Quite High
fibrosis 7 37.44 Quite Low
Arthritis 126 27.52 Quite Low
rheumatoid arthritis 28 5.00 Very Low Very Low Very Low
antagonist 14 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 172 75.36 Quite High
Coronary Heart Disease 1 70.16 Quite High
Arthropathy 15 68.88 Quite High
Hypercalcemia 21 65.04 Quite High
Bacterial Respiratory Disease 1 56.68 Quite High
INFLAMMATION 135 50.00 Quite Low
Eczema 4 49.36 Quite Low
Fibrosis 6 37.44 Quite Low
Skin Diseases 2 26.32 Quite Low
Pressure And Volume Under Development 30 19.92 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Once activated, calcineurin directly dephosphorylates nuclear factor of activated T cells (NFAT)4 transcription factors within the cytoplasm, promoting their translocation into the nucleus and the activation of gene expression (2).
Localization (translocation) of NFAT in NFAT
1) Confidence 0.57 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2825466 Disease Relevance 0.07 Pain Relevance 0
NFATc1 is dephosphorylated upon activation by calcineurin in the cell cytoplasm and then translocated to the nucleus.
Localization (translocated) of NFATc1 in nucleus
2) Confidence 0.55 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0 Pain Relevance 0.09
MDL-1 + RANKL induced a significant increase of phospho-NFATc1 nuclear localization over RANKL alone, indicating that MDL-1-DAP12–mediated signaling promotes amplification of this transcription regulator required for osteoclast differentiation (Fig. 5 C).
Localization (localization) of NFATc1 in osteoclast
3) Confidence 0.48 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.27 Pain Relevance 0.11
MDL-1 + RANKL induced a significant increase of phospho-NFATc1 nuclear localization over RANKL alone, indicating that MDL-1-DAP12–mediated signaling promotes amplification of this transcription regulator required for osteoclast differentiation (Fig. 5 C).
Localization (localization) of NFATc1 in osteoclast
4) Confidence 0.48 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.27 Pain Relevance 0.11
B and NFAT are located in the twist1 promoter at positions ?
Localization (located) of NFAT
5) Confidence 0.14 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0 Pain Relevance 0
Upon dephosphorylation, NFAT translocates to the nucleus, where it binds its nuclear counterpart to form an active transcription factor inducing the production of several cytokines mandatory for initiating an immune response.
Localization (translocates) of NFAT in nucleus associated with cytokine
6) Confidence 0.04 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1386691 Disease Relevance 0.06 Pain Relevance 0.05

General Comments

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