INT190678

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.26
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.04
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nfatc1) DNA binding (Nfatc1) cytoplasm (Nfatc1)
Anatomy Link Frequency
NFAT 2
proximal 1
nucleus 1
Nfatc1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 99 98.16 Very High Very High Very High
Inflammation 140 89.84 High High
agonist 20 83.32 Quite High
dorsal root ganglion 3 79.36 Quite High
Demyelination 6 60.72 Quite High
Arthritis 58 17.96 Low Low
fibrosis 1 5.84 Low Low
rheumatoid arthritis 20 5.00 Very Low Very Low Very Low
Crohn's disease 7 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 4 99.12 Very High Very High Very High
INFLAMMATION 137 89.84 High High
Ganglion Cysts 3 79.36 Quite High
Adhesions 3 63.36 Quite High
Demyelinating Disease 7 60.72 Quite High
Asthma 6 59.72 Quite High
Bacterial Respiratory Disease 1 56.68 Quite High
Eczema 4 51.84 Quite High
Hyperplasia 4 46.92 Quite Low
Skin Diseases 2 28.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The primary antibody specifically binds the accessible epitope on the NFATc1 protein.
NFATc1 Binding (binds) of
1) Confidence 0.26 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0 Pain Relevance 0.11
The proximal promoter of twist1 contains phylogenetically conserved binding sites for NFAT, NF-?
NFAT Binding (binding) of in proximal
2) Confidence 0.07 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.23 Pain Relevance 0.11
In addition to transcription factors that promote myelination, such as NFAT, NF-?
NFAT Binding (addition) of
3) Confidence 0.05 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948355 Disease Relevance 0.42 Pain Relevance 0.10
The nuclear factor of activated T cells (NFAT) family of transcription factors has a critical role in T cell effector functions, and NFAT DNA-binding sites have been identified in many different cytokine genes, for example those of IL-2, IL-4, and IFN-?
NFAT Binding (binding) of in NFAT associated with cytokine
4) Confidence 0.02 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.15 Pain Relevance 0.25
The nuclear factor of activated T cells (NFAT) family of transcription factors has a critical role in T cell effector functions, and NFAT DNA-binding sites have been identified in many different cytokine genes, for example those of IL-2, IL-4, and IFN-?
NFAT Binding (binding) of in NFAT associated with cytokine
5) Confidence 0.02 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.14 Pain Relevance 0.21
Upon dephosphorylation, NFAT translocates to the nucleus, where it binds its nuclear counterpart to form an active transcription factor inducing the production of several cytokines mandatory for initiating an immune response.
NFAT Binding (binds) of in nucleus associated with cytokine
6) Confidence 0.02 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1386691 Disease Relevance 0.11 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox