INT190683

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Context Info
Confidence 0.11
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.97
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (A2M, INS) extracellular region (A2M, INS) cytosol (A2M)
small molecule metabolic process (INS) carbohydrate metabolic process (INS) enzyme binding (A2M)
Anatomy Link Frequency
plasma 2
A2M (Homo sapiens)
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 319 86.04 High High
Inflammation 28 63.84 Quite High
alcohol 36 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 13 100.00 Very High Very High Very High
Diabetes Mellitus 22 99.36 Very High Very High Very High
Fatty Liver 118 98.96 Very High Very High Very High
Cirrhosis 86 86.04 High High
Hepatitis 27 84.68 Quite High
Fibrosis 298 82.60 Quite High
Congenital Anomalies 3 80.32 Quite High
Liver Disease 27 79.16 Quite High
Alcoholic Liver Diseases 29 77.04 Quite High
Disorder Of Lipid Metabolism 41 73.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Insulin is covalently bound to A2M [42] in plasma and A2M is a binding protein of Insulin-like Growth Factor Binding Protein-1 (IGFBP-1) which modifies the IGFBP-1/IGF interaction [43].
A2M Binding (bound) of Insulin in plasma
1) Confidence 0.11 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.48 Pain Relevance 0.04
Interestingly, in patients with NAFLD, the present study demonstrated a very significant association between A2M and insulin levels, a hallmark of insulin resistance.
A2M Binding (association) of insulin associated with fatty liver and insulin resistance
2) Confidence 0.00 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1386692 Disease Relevance 1.04 Pain Relevance 0.07
Interestingly, in patients with NAFLD, the present study demonstrated a very significant association between A2M and insulin levels, a hallmark of insulin resistance.
A2M Binding (association) of insulin associated with fatty liver and insulin resistance
3) Confidence 0.00 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1386692 Disease Relevance 1.15 Pain Relevance 0.10
Insulin is covalently bound to A2M in plasma [49] and A2M is a binding protein of Insulin-like Growth Factor Binding Protein-1 (IGFBP-1) which modifies the IGFBP-1/IGF interaction [50].
A2M Binding (bound) of Insulin in plasma
4) Confidence 0.00 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1386692 Disease Relevance 1.30 Pain Relevance 0.10

General Comments

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