INT190703

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Context Info
Confidence 0.06
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.08
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TSC1) embryo development (TSC1) protein complex (TSC1)
cytoplasm (TSC1)
Anatomy Link Frequency
colon 2
TSC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 2 75.76 Quite High
drug abuse 2 73.04 Quite High
Pain 1 7.60 Low Low
cytokine 42 5.00 Very Low Very Low Very Low
Inflammation 39 5.00 Very Low Very Low Very Low
tolerance 9 5.00 Very Low Very Low Very Low
cva 6 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 287 100.00 Very High Very High Very High
Colon Cancer 25 99.84 Very High Very High Very High
Chondrosarcoma 52 98.80 Very High Very High Very High
Congenital Anomalies 4 87.20 High High
Drug Dependence 2 73.04 Quite High
Apoptosis 48 68.52 Quite High
Malignant Neoplastic Disease 27 63.92 Quite High
Chondroma 1 45.36 Quite Low
Stress 4 44.12 Quite Low
Breast Cancer 6 42.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A number of miRNAs were discovered to be deregulated due to the loss of the p53 tumor suppressor in colon cancer cell lines.
Regulation (deregulated) of Negative_regulation (loss) of tumor suppressor in colon associated with cancer and colon cancer
1) Confidence 0.06 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.72 Pain Relevance 0
Later, this hypothesis led to the mutagenic and recently the oncogenic theories which hypothesize that defects in tumor suppressor genes are responsible for the development of cancer [3].
Regulation (responsible) of Negative_regulation (defects) of tumor suppressor associated with cancer
2) Confidence 0.01 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1386699 Disease Relevance 0.98 Pain Relevance 0.07
The role of the loss of tumor suppressor genes is one well-known cause of radioresistance in numerous tumors.
Regulation (role) of Negative_regulation (loss) of tumor suppressor associated with cancer
3) Confidence 0.01 Published 2011 Journal Sarcoma Section Body Doc Link PMC3018623 Disease Relevance 1.38 Pain Relevance 0

General Comments

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