INT19071

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.81
First Reported 1981
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 66
Total Number 66
Disease Relevance 5.10
Pain Relevance 16.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Ache) extracellular space (Ache) extracellular region (Ache)
cell adhesion (Ache) Golgi apparatus (Ache) plasma membrane (Ache)
Anatomy Link Frequency
substantia nigra 16
myotubes 5
brains 3
striatum 3
nerve 3
Ache (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 38 100.00 Very High Very High Very High
Dopamine 11 100.00 Very High Very High Very High
Enkephalin 4 100.00 Very High Very High Very High
Catecholamine 2 100.00 Very High Very High Very High
Opioid 1 100.00 Very High Very High Very High
Substantia nigra 170 99.88 Very High Very High Very High
Botox 135 99.72 Very High Very High Very High
anesthesia 20 99.50 Very High Very High Very High
substance P 13 99.40 Very High Very High Very High
IPN 10 98.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cirrhosis 133 100.00 Very High Very High Very High
Arrhythmias 2 Under Development 8 99.84 Very High Very High Very High
Movement Disorders 18 92.68 High High
Urological Neuroanatomy 50 89.72 High High
Neuroblastoma 2 89.64 High High
Congenital Anomalies 7 86.56 High High
Toxicity 3 85.04 High High
Liver Disease 56 81.56 Quite High
Gastroenteritis 3 79.40 Quite High
Pain 5 77.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have measured acetylcholinesterase (AChE) turnover and secretion in spontaneously fibrillating rat myotubes and in cultures in which fibrillation was blocked with tetrodotoxin.
Localization (secretion) of acetylcholinesterase in myotubes associated with tetrodotoxin and arrhythmias 2 under development
1) Confidence 0.81 Published 1986 Journal Brain Res. Section Abstract Doc Link 3730845 Disease Relevance 0.17 Pain Relevance 0.10
Effect of fibrillation on the secretion of acetylcholinesterase from cultured embryonic rat myotubes.
Localization (secretion) of acetylcholinesterase in myotubes associated with arrhythmias 2 under development
2) Confidence 0.81 Published 1986 Journal Brain Res. Section Title Doc Link 3730845 Disease Relevance 0.19 Pain Relevance 0.09
Ranitidine showed the anti-AchE activity and increased duodenal HCO(3)(-) secretion, similar to nizatidine, whereas famotidine had any influence on neither AChE activity nor the HCO(3)(-) secretion.
Localization (secretion) of AChE
3) Confidence 0.81 Published 2001 Journal J. Physiol. Paris Section Abstract Doc Link 11595432 Disease Relevance 0.05 Pain Relevance 0.10
On the other hand, release of acetylcholinesterase from the substantia nigra, which probably occurs from dendrites, is independent of Na+ mediated action potentials.
Localization (release) of acetylcholinesterase in substantia nigra associated with action potential and substantia nigra
4) Confidence 0.80 Published 1986 Journal Neuroscience Section Abstract Doc Link 3714040 Disease Relevance 0 Pain Relevance 0.36
In the second part of this study we studied the relationship between firing rate of nigrostriatal cells and the release of acetylcholinesterase.
Localization (release) of acetylcholinesterase
5) Confidence 0.80 Published 1986 Journal Neuroscience Section Abstract Doc Link 3714040 Disease Relevance 0 Pain Relevance 0.29
These results suggest that release of acetylcholinesterase in the striatum may be linked to the discharge frequency of nigrostriatal neurons.
Localization (release) of acetylcholinesterase in striatum
6) Confidence 0.80 Published 1986 Journal Neuroscience Section Abstract Doc Link 3714040 Disease Relevance 0 Pain Relevance 0.36
In the ipsilateral striatum, the release of acetylcholinesterase was modified in a fashion reminiscent of the changes in firing rate induced by these drugs in nigrostriatal cells.
Localization (release) of acetylcholinesterase in striatum
7) Confidence 0.80 Published 1986 Journal Neuroscience Section Abstract Doc Link 3714040 Disease Relevance 0 Pain Relevance 0.08
Acetylcholinesterase is released from both axon terminals and dendrites of nigrostriatal neurons.
Localization (released) of Acetylcholinesterase in neurons
8) Confidence 0.80 Published 1986 Journal Neuroscience Section Abstract Doc Link 3714040 Disease Relevance 0 Pain Relevance 0.03
Both compounds reduced the release of acetylcholinesterase in the ipsilateral striatum.
Localization (release) of acetylcholinesterase in striatum
9) Confidence 0.80 Published 1986 Journal Neuroscience Section Abstract Doc Link 3714040 Disease Relevance 0 Pain Relevance 0.36
In fact, following administration of gamma-hydroxybutyrate, there was a large Ca2+ dependent increase in release of acetylcholinesterase in the substantia nigra.
Localization (release) of acetylcholinesterase in substantia nigra associated with substantia nigra
10) Confidence 0.80 Published 1986 Journal Neuroscience Section Abstract Doc Link 3714040 Disease Relevance 0 Pain Relevance 0.36
Thus, application of acetylcholine into the substantia nigra induced an increase, while apomorphine induced a decrease in the release of acetylcholinesterase from the striatum.
Localization (release) of acetylcholinesterase in substantia nigra associated with substantia nigra
11) Confidence 0.80 Published 1986 Journal Neuroscience Section Abstract Doc Link 3714040 Disease Relevance 0 Pain Relevance 0.20
However, in the substantia nigra, the release of acetylcholinesterase did not follow this pattern: acetylcholine reduced local release, while apomorphine caused no change.
Localization (release) of acetylcholinesterase in substantia nigra associated with substantia nigra
12) Confidence 0.80 Published 1986 Journal Neuroscience Section Abstract Doc Link 3714040 Disease Relevance 0 Pain Relevance 0.23
Although neuronal colocalization of ChAT and AChE activity is not evident in the IPN, AChE-positive neurons are in receipt of putative cholinergic, as well as peptidergic, afferent inputs.
Localization (colocalization) of AChE in neurons associated with ipn
13) Confidence 0.80 Published 1990 Journal Brain Res. Bull. Section Abstract Doc Link 2337826 Disease Relevance 0 Pain Relevance 0.40
In addition, release of acetylcholinesterase could be evoked by either pharmacological or physiological manipulations, i.e. (1) a depolarizing concentration of potassium ions administered locally; (2) metamphetamine, administered systematically, which also resulted in increased locomotor activity; (3) drinking behaviour, elicited by presentation of a water bottle.
Localization (release) of acetylcholinesterase associated with eae
14) Confidence 0.79 Published 1990 Journal Neuroscience Section Abstract Doc Link 2243598 Disease Relevance 0 Pain Relevance 0.23
Acetylcholinesterase is released from dopaminergic cells within the substantia nigra.
Localization (released) of Acetylcholinesterase in substantia nigra associated with substantia nigra
15) Confidence 0.79 Published 1990 Journal Neuroscience Section Abstract Doc Link 2243598 Disease Relevance 0 Pain Relevance 0.13
In the unanaesthetized guinea-pig the amount of acetylcholinesterase released was significantly greater than during anaesthesia, and release occurred in a more pulsatile manner.
Localization (released) of acetylcholinesterase
16) Confidence 0.79 Published 1990 Journal Neuroscience Section Abstract Doc Link 2243598 Disease Relevance 0 Pain Relevance 0.19
Immunohistochemical examination of BDL and NL rat brains show that the subcellular localization of both, AChE and ChAT, and thus the accessibility to their substrates, appears unaltered by the pathological condition.
Localization (localization) of AChE in brains
17) Confidence 0.79 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 0.09 Pain Relevance 0
No difference observed in the localization and intensity of the AChE and ChAT immunoreactivity in all the analysed coronal sections of control NL (n = 3), BDL (n = 3) and BDL + HD (n = 3) rats.
Localization (localization) of AChE
18) Confidence 0.79 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 0.23 Pain Relevance 0.17
Acetylcholinesterase (AChE) is released from dopaminergic dendrites in the guinea-pig substantia nigra.
Localization (eleased ) of AChE in substantia nigra associated with substantia nigra
19) Confidence 0.79 Published 1994 Journal Neuroreport Section Abstract Doc Link 8018847 Disease Relevance 0 Pain Relevance 0.31
Application of exogenous 5-hydroxytryptamine (5-HT) directly to the substantia nigra similarly enhanced release of AChE, whilst local application of cinanserin, a 5-HT antagonist, inhibited electrically-evoked release.
Localization (lease o) of AChE in substantia nigra associated with antagonist and substantia nigra
20) Confidence 0.79 Published 1994 Journal Neuroreport Section Abstract Doc Link 8018847 Disease Relevance 0 Pain Relevance 0.40

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox