INT19072

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Context Info
Confidence 0.62
First Reported 1989
Last Reported 2010
Negated 3
Speculated 3
Reported most in Abstract
Documents 14
Total Number 17
Disease Relevance 2.74
Pain Relevance 5.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Ache) extracellular space (Ache) extracellular region (Ache)
cell adhesion (Ache) Golgi apparatus (Ache) plasma membrane (Ache)
Anatomy Link Frequency
striatum 4
neural 4
spinal 2
liver 2
muscle 2
Ache (Rattus norvegicus)
Pain Link Frequency Relevance Heat
methadone 14 100.00 Very High Very High Very High
qutenza 7 100.00 Very High Very High Very High
electroacupuncture 6 100.00 Very High Very High Very High
spinal dorsal horn 5 98.60 Very High Very High Very High
Endogenous opioid 3 98.56 Very High Very High Very High
Dynorphin 10 97.36 Very High Very High Very High
tetrodotoxin 23 97.20 Very High Very High Very High
Sciatic nerve 2 94.52 High High
palliative 1 93.28 High High
Central grey 2 92.04 High High
Disease Link Frequency Relevance Heat
Liver Failure 20 99.64 Very High Very High Very High
Sprains And Strains 2 98.12 Very High Very High Very High
Hepatic Encephalopathy 34 97.76 Very High Very High Very High
Cognitive Disorder 36 96.52 Very High Very High Very High
Disease 4 95.76 Very High Very High Very High
Alzheimer's Dementia 8 95.48 Very High Very High Very High
Urological Neuroanatomy 17 92.04 High High
Hyperammonemia 8 85.68 High High
Toxicity 2 80.80 Quite High
Paralysis 1 79.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Factors regulating the expression of acetylcholinesterase-containing neurons in striatal cultures: effects of chemical depolarization.
Regulation (regulating) of Gene_expression (expression) of acetylcholinesterase in neurons
1) Confidence 0.62 Published 1990 Journal Brain Res. Section Title Doc Link 2178031 Disease Relevance 0 Pain Relevance 0.06
To determine if AChE expression is altered in BDL rats, we performed QRT-PCR analysis of the AChE mRNA.
Regulation (altered) of Spec (determine) Gene_expression (expression) of AChE
2) Confidence 0.60 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 0.06 Pain Relevance 0.14
Together, these results illustrate that, in addition to neural activation and trophic factors, passive mechanical forces modulate expression of AChE in skeletal muscle cells.
Regulation (modulate) of Gene_expression (expression) of AChE in neural
3) Confidence 0.60 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9435507 Disease Relevance 0.07 Pain Relevance 0.27
Although mechanical stimulation did not affect AChE expression at early time points, it led to a significant increase (42%; P < 0.05) in total AChE activity at 24 h.
Neg (not) Regulation (affect) of Gene_expression (expression) of AChE
4) Confidence 0.60 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9435507 Disease Relevance 0.10 Pain Relevance 0.16
In order to establish whether contractile activity modulates the rate of AChE transcript synthesis, and what elements of the gene are determinant, we examined the promoter and intron I in contracting muscle cultures.
Spec (whether) Regulation (modulates) of Gene_expression (synthesis) of AChE in muscle
5) Confidence 0.59 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16787423 Disease Relevance 0.08 Pain Relevance 0.14
In addition, taking together our results and data from the literature. we conclude that the expression of AChE molecular forms depends both on the species and on the culture conditions used.
Regulation (depends) of Gene_expression (expression) of AChE
6) Confidence 0.54 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 2013753 Disease Relevance 0 Pain Relevance 0.23
The effect of prenatal exposure to methadone via maternal osmotic minipumps on the expression of acetylcholinesterase (AChE) and choline acetyltransferase (ChAT) has been studied by light microscopy in the striatum of male and female rats.
Regulation (effect) of Gene_expression (expression) of AChE in striatum associated with methadone
7) Confidence 0.53 Published 1993 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 8149590 Disease Relevance 0 Pain Relevance 0.31
The present studies were undertaken to determine the effects of reduced afferent neural activity on expression of the transient pattern of AChE activity.
Spec (determine) Regulation (effects) of Gene_expression (expression) of AChE in neural
8) Confidence 0.45 Published 1989 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 2706772 Disease Relevance 0 Pain Relevance 0.32
[Influence of electroacupuncture and capsaicin treatment on AChE activity and [3H]-QNB binding sites in the spinal dorsal horn].
Regulation ([Influence) of Gene_expression (activity) of AChE in spinal associated with qutenza, spinal dorsal horn and electroacupuncture
9) Confidence 0.45 Published 1996 Journal Zhen Ci Yan Jiu Section Title Doc Link 9387374 Disease Relevance 0 Pain Relevance 1.23
The effect of prenatal exposure to methadone via maternal osmotic minipumps on the expression of acetylcholinesterase (AChE) and choline acetyltransferase (ChAT) has been studied by light microscopy in the striatum of male and female rats.
Regulation (effect) of Gene_expression (expression) of acetylcholinesterase in striatum associated with methadone
10) Confidence 0.45 Published 1993 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 8149590 Disease Relevance 0 Pain Relevance 0.31
BDL rats, an animal model of liver failure, showed the same degree of alteration in both, AChE and ACh levels, as the BDL + HD animals, a model of liver failure and HE.
Regulation (degree) of Gene_expression (levels) of AChE in liver associated with liver failure and hepatic encephalopathy
11) Confidence 0.44 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 1.03 Pain Relevance 0.08
They also showed little or no change in staining for NPY, acetylcholinesterase (AChE) and tyrosine hydroxylase (TH) and essentially normal striatal gross morphology.
Neg (little) Regulation (change) of Gene_expression (staining) of AChE
12) Confidence 0.42 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10648885 Disease Relevance 0 Pain Relevance 0.27
They also showed little or no change in staining for NPY, acetylcholinesterase (AChE) and tyrosine hydroxylase (TH) and essentially normal striatal gross morphology.
Neg (little) Regulation (change) of Gene_expression (staining) of acetylcholinesterase
13) Confidence 0.42 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10648885 Disease Relevance 0 Pain Relevance 0.27
As the acetylcholinesterase expression in the patches is known to match in detail choline acetyltransferase expression, our results also suggest the possibility of local cholinergic-opiatergic interactions.
Regulation (match) of Gene_expression (expression) of acetylcholinesterase
14) Confidence 0.37 Published 1994 Journal J. Comp. Neurol. Section Abstract Doc Link 8188852 Disease Relevance 0.17 Pain Relevance 0.63
In addition to their catalytic effects, there is a suggestion that AChE inhibitors may influence expression of AChE isoforms and increase expression of nicotinic receptors, both of which correlate with cognitive improvements in AD patients.
Regulation (influence) of Gene_expression (expression) of AChE associated with cognitive disorder and alzheimer's dementia
15) Confidence 0.33 Published 2006 Journal Alzheimer Dis Assoc Disord Section Abstract Doc Link 16772751 Disease Relevance 0.93 Pain Relevance 0.31
We have also seen similar changes in AChE and FGF-2 expression in cortex of animals with 60 days of complex housing (Kolb et al., 1998).
Regulation (changes) of Gene_expression (expression) of AChE in cortex
16) Confidence 0.30 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC2991189 Disease Relevance 0.31 Pain Relevance 0.18
Likewise, both the synthesis and secretion of AChE are shown to be locally regulated.
Regulation (regulated) of Gene_expression (synthesis) of AChE
17) Confidence 0.28 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10648696 Disease Relevance 0 Pain Relevance 0.38

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