INT190750

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Context Info
Confidence 0.11
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adcyap1, Adcyap1r1) cell differentiation (Adcyap1r1) endosome (Adcyap1r1)
cytoplasm (Adcyap1r1) signal transducer activity (Adcyap1r1) extracellular space (Adcyap1)
Adcyap1 (Mus musculus)
Adcyap1r1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 12 65.92 Quite High
agonist 10 60.20 Quite High
imagery 14 45.04 Quite Low
Glutamate 32 40.40 Quite Low
addiction 2 22.24 Low Low
tetrodotoxin 4 5.00 Very Low Very Low Very Low
Neuropeptide 4 5.00 Very Low Very Low Very Low
Glutamate receptor 4 5.00 Very Low Very Low Very Low
gABA 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 12 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 6 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This data suggests that PACAP can modulate AMPA currents through a PAC1 receptor mediated activation of the AC/PKA signalling pathway.


PACAP Regulation (modulate) of Positive_regulation (activation) of PAC1 receptor
1) Confidence 0.11 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1388226 Disease Relevance 0 Pain Relevance 0.06
The simplest explanation for our data is that PACAP modulate glutamatergic signalling through a PAC1 receptor mediated activation of AC activity.
PACAP Regulation (modulate) of Positive_regulation (activation) of PAC1 receptor
2) Confidence 0.09 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1388226 Disease Relevance 0 Pain Relevance 0

General Comments

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