INT190751

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Context Info
Confidence 0.16
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.02
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adcyap1, Vipr2) extracellular space (Adcyap1) extracellular region (Adcyap1)
plasma membrane (Vipr2) signal transducer activity (Vipr2)
Anatomy Link Frequency
neuronal 1
Adcyap1 (Mus musculus)
Vipr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Substantia nigra 4 98.44 Very High Very High Very High
agonist 5 89.68 High High
Inflammatory mediators 2 88.00 High High
antagonist 7 79.12 Quite High
Glutamate receptor 2 53.52 Quite High
Neuropeptide 15 50.00 Quite Low
Glutamate 16 34.96 Quite Low
Hippocampus 1 32.28 Quite Low
imagery 7 30.56 Quite Low
Central nervous system 23 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 23 99.92 Very High Very High Very High
Autoimmune Disease 15 92.12 High High
INFLAMMATION 19 88.00 High High
Fatigue 11 86.52 High High
Drug Induced Neurotoxicity 1 85.36 High High
Stress 1 82.32 Quite High
Apoptosis 2 81.72 Quite High
Parkinson's Disease 1 76.52 Quite High
Increased Venous Pressure Under Development 2 70.36 Quite High
Neuromyelitis Optica 1 49.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PACAP activates receptors of PAC1R, VPAC1R, and VPAC2R families, and PACAP has been identified widely in the brain including the SN as well as in other organs and blood cells.56 Moreover, PACAP has been shown to be effective in treatment in rat models of PD.57 Both PACAP and VIP have neuroprotective effects in PD models by inhibiting the production of inflammatory mediators.58 PACAP specifically protects against the neurotoxicity induced by rotenone59 as well as protecting against oxidative stress-induced apoptosis.60 In a murine model for PD, Delgado and Ganea61 note that the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) activates microglia and promotes dopaminergic neuronal loss.
PACAP Positive_regulation (activates) of VPAC2R in neuronal associated with parkinson's disease, stress, inflammatory mediators, drug induced neurotoxicity, substantia nigra, apoptosis and disease
1) Confidence 0.16 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 1.02 Pain Relevance 0.19
The PAC1 receptor is more selective for PACAP while the VPAC1 and VPAC2 receptors can be potently activated by VIP or PACAP [38].
PACAP Positive_regulation (activated) of VPAC2
2) Confidence 0.12 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1388226 Disease Relevance 0 Pain Relevance 0.17

General Comments

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