INT19078

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Context Info
Confidence 0.48
First Reported 1986
Last Reported 2011
Negated 3
Speculated 6
Reported most in Abstract
Documents 78
Total Number 86
Disease Relevance 31.03
Pain Relevance 44.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngf) extracellular space (Ngf) aging (Ngf)
extracellular region (Ngf) molecular_function (Ngf)
Anatomy Link Frequency
nerve 22
brain 2
neurite 2
testis 2
sympathetic 2
Ngf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 4109 100.00 Very High Very High Very High
Hyperalgesia 122 100.00 Very High Very High Very High
Spinal cord 116 100.00 Very High Very High Very High
Inflammatory mediators 67 100.00 Very High Very High Very High
dorsal root ganglion 56 100.00 Very High Very High Very High
Neuritis 3 100.00 Very High Very High Very High
Peripheral nerve injury 3 100.00 Very High Very High Very High
Acupuncture 294 99.98 Very High Very High Very High
nociceptor 145 99.96 Very High Very High Very High
tetrodotoxin 12 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 346 100.00 Very High Very High Very High
INFLAMMATION 311 100.00 Very High Very High Very High
Ganglion Cysts 182 100.00 Very High Very High Very High
Hyperalgesia 177 100.00 Very High Very High Very High
Wound Healing 13 100.00 Very High Very High Very High
Neuritis 3 100.00 Very High Very High Very High
Diabetes Mellitus 3 100.00 Very High Very High Very High
Polycystic Ovary Syndrome 320 99.80 Very High Very High Very High
Pain 157 99.76 Very High Very High Very High
Nociception 135 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, we have shown that the interaction between NGF and sensory neurons in early postnatal periods is restricted to nociceptive afferents (Ritter et al., 1991; Lewin et al., 1992a; Ritter and Mendell, 1992).
NGF Binding (interaction) of in sensory neurons associated with nociception
1) Confidence 0.48 Published 1993 Journal J. Neurosci. Section Abstract Doc Link 8478693 Disease Relevance 0.44 Pain Relevance 0.35
We measured the in vitro laminin-binding activities of NAT-NGF and LBD-NGF by ELISA.
NAT-NGF Binding (activities) of associated with nerve growth factor
2) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2703785 Disease Relevance 0.18 Pain Relevance 0.91
In order to validate its targeting effects, the laminin-binding activity of LBD-NGF was tested in vitro.
LBD-NGF Binding (activity) of associated with nerve growth factor
3) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2703785 Disease Relevance 0.15 Pain Relevance 0.55
Biochemical studies have shown that domain 5 of the TrkA (tropomyosin receptor kinase A) receptor is involved in the binding of NGF (nerve growth factor).
NGF Binding (binding) of in nerve associated with nerve growth factor
4) Confidence 0.47 Published 2006 Journal Biochem. Soc. Trans. Section Abstract Doc Link 16856868 Disease Relevance 0 Pain Relevance 0.12
Crystallographic studies have confirmed this, demonstrating that one homodimer of NGF binds to two TrkAd5 molecules.
NGF Binding (binds) of
5) Confidence 0.47 Published 2006 Journal Biochem. Soc. Trans. Section Abstract Doc Link 16856868 Disease Relevance 0.11 Pain Relevance 0.18
Biochemical studies have shown that domain 5 of the TrkA (tropomyosin receptor kinase A) receptor is involved in the binding of NGF (nerve growth factor).
nerve growth factor Binding (binding) of in nerve associated with nerve growth factor
6) Confidence 0.47 Published 2006 Journal Biochem. Soc. Trans. Section Abstract Doc Link 16856868 Disease Relevance 0 Pain Relevance 0.12
TrkAd5 has been made recombinantly in Escherichia coli, purified and shown to bind NGF with picomolar affinity.
NGF Binding (bind) of
7) Confidence 0.47 Published 2006 Journal Biochem. Soc. Trans. Section Abstract Doc Link 16856868 Disease Relevance 0.13 Pain Relevance 0.19
The results of ET-1 concentrations in the adrenal glands and NGF in the spinal cord and in the adrenal glands indicate a close interaction between these two systems, most likely due to the fact that the adrenal glands are part of the sympathetic nervous system.
NGF Spec (likely) Binding (interaction) of in adrenal glands associated with nerve growth factor and spinal cord
8) Confidence 0.47 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC155675 Disease Relevance 0.35 Pain Relevance 0.72
Specific NGF binding was assessed by use of monoclonal mouse anti ?
NGF Binding (binding) of associated with nerve growth factor
9) Confidence 0.47 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC155675 Disease Relevance 0 Pain Relevance 0.49
By means of quantitative RT-PCR we demonstrate that the upper and lower part of the bladder and the urethra express estrogen receptor of the alpha- and beta-subtype (ER alpha and beta) and nerve growth factor, which is associated with painful sensations in inflamed urinary bladders.
nerve growth factor Binding (associated) of in upper associated with pain, stress incontinence and nerve growth factor
10) Confidence 0.46 Published 2004 Journal Endocrine Section Abstract Doc Link 15034193 Disease Relevance 0.54 Pain Relevance 0.18
Also in the pancreas, NGF was associated with pain and it can stimulate the proliferation of pancreatic cancer cells.
NGF Binding (associated) of in pancreas associated with pain, nerve growth factor and pancreatic cancer
11) Confidence 0.44 Published 2009 Journal Growth Factors Section Abstract Doc Link 19639490 Disease Relevance 0.85 Pain Relevance 0.62
We measured the in vitro laminin-binding activities of NAT-NGF and LBD-NGF by ELISA.
LBD-NGF Binding (activities) of associated with nerve growth factor
12) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2703785 Disease Relevance 0.18 Pain Relevance 0.92
However, a recent study did not demonstrate an association of increased urothelium/suburothelium NGF with detrusor overactivity [12].
NGF Neg (not) Binding (association) of associated with nerve growth factor and overactive bladder
13) Confidence 0.40 Published 2007 Journal BMC Physiol Section Body Doc Link PMC2000875 Disease Relevance 1.55 Pain Relevance 1.09
The rat clonal pheochromocytoma cell line PC12 can be induced to display neurite outgrowth upon induction with nerve growth factor (NGF).
nerve growth factor Binding (induction) of in nerve associated with nerve growth factor and pheochromocytoma
14) Confidence 0.37 Published 1995 Journal J. Cancer Res. Clin. Oncol. Section Abstract Doc Link 7593129 Disease Relevance 0.17 Pain Relevance 0.34
The rat clonal pheochromocytoma cell line PC12 can be induced to display neurite outgrowth upon induction with nerve growth factor (NGF).
NGF Binding (induction) of in nerve associated with nerve growth factor and pheochromocytoma
15) Confidence 0.37 Published 1995 Journal J. Cancer Res. Clin. Oncol. Section Abstract Doc Link 7593129 Disease Relevance 0.17 Pain Relevance 0.34
Intraplantar injections of nerve growth factor (NGF; five injections of 4 micrograms each in 30 h intervals) were able to locally improve the recovery of the noradrenaline content in 6-hydroxydopamine (6-OHDA)-lesioned sympathetic nerves in adult rats.
nerve growth factor Binding (injections) of in sympathetic associated with nerve growth factor and noradrenaline
16) Confidence 0.37 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 9014174 Disease Relevance 0 Pain Relevance 0.24
Intraplantar injections of nerve growth factor (NGF; five injections of 4 micrograms each in 30 h intervals) were able to locally improve the recovery of the noradrenaline content in 6-hydroxydopamine (6-OHDA)-lesioned sympathetic nerves in adult rats.
NGF Binding (injections) of in sympathetic associated with nerve growth factor and noradrenaline
17) Confidence 0.37 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 9014174 Disease Relevance 0 Pain Relevance 0.24
Cellular pathology changes in rat skin following intradermal injection of nerve growth factor: neutrophil-dependent and -independent events.
nerve growth factor Binding (injection) of in nerve associated with nerve growth factor
18) Confidence 0.37 Published 2002 Journal J. Pathol. Section Title Doc Link 12015750 Disease Relevance 0.42 Pain Relevance 0.57
AIMS: To investigate whether local administration of nerve growth factor (NGF) decreases the mechanical threshold (MT) of putative nociceptive masseter afferent fibers as part of its mechanism of mechanical sensitization.
NGF Spec (whether) Binding (administration) of in nerve associated with nociception and nerve growth factor
19) Confidence 0.37 Published 2006 Journal J Orofac Pain Section Abstract Doc Link 17190031 Disease Relevance 0.10 Pain Relevance 0.09
AIMS: To investigate whether local administration of nerve growth factor (NGF) decreases the mechanical threshold (MT) of putative nociceptive masseter afferent fibers as part of its mechanism of mechanical sensitization.
nerve growth factor Spec (whether) Binding (administration) of in nerve associated with nociception and nerve growth factor
20) Confidence 0.37 Published 2006 Journal J Orofac Pain Section Abstract Doc Link 17190031 Disease Relevance 0.10 Pain Relevance 0.09

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