INT190781

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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 9.12
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Acsl1) endoplasmic reticulum (Acsl1) plasma membrane (Acsl1)
peroxisome (Acsl1) ligase activity (Acsl1) lipid metabolic process (Acsl1)
Anatomy Link Frequency
platelet 3
embryos 1
neurons 1
plaque 1
Acsl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 39 96.12 Very High Very High Very High
Inflammation 22 95.64 Very High Very High Very High
Spinal cord 14 92.84 High High
Anterior cingulate cortex 21 92.20 High High
cva 37 86.48 High High
nMDA receptor 8 59.68 Quite High
fibrosis 3 58.20 Quite High
Calcium channel 2 56.72 Quite High
spinal dorsal horn 1 43.84 Quite Low
Hippocampus 2 10.16 Low Low
Disease Link Frequency Relevance Heat
Acute Coronary Syndrome 344 100.00 Very High Very High Very High
Rupture 8 99.90 Very High Very High Very High
Atherosclerotic Plaque 8 99.60 Very High Very High Very High
Thrombosis 16 99.08 Very High Very High Very High
Myalgia 29 96.12 Very High Very High Very High
Necrosis 4 96.08 Very High Very High Very High
INFLAMMATION 22 95.64 Very High Very High Very High
Coronary Artery Disease 228 94.48 High High
Pathologic Constriction 3 92.12 High High
Myocardial Infarction 56 90.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dissociation of zebrafish embryos and FACS
FACS Binding (Dissociation) of in embryos
1) Confidence 0.36 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2940735 Disease Relevance 0 Pain Relevance 0
The significantly high frequency of eNOS -786C/C genotype in ACS patients than in those of controls, indicate the genotype association with ACS.
ACS Binding (association) of associated with acute coronary syndrome
2) Confidence 0.18 Published 2008 Journal Lipids Health Dis Section Abstract Doc Link PMC2267783 Disease Relevance 1.38 Pain Relevance 0
In the present study, the frequency of eNOS -786C/C genotype was found to be significantly higher in ACS patients (50%) than in those of controls (6.5%), which indicate the association of -786C/C genotype with ACS.
ACS Binding (association) of associated with acute coronary syndrome
3) Confidence 0.18 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2267783 Disease Relevance 1.41 Pain Relevance 0.07
In conclusion, The significantly high frequency of eNOS -786C/C genotype in ACS patients than in those of controls, indicate the genotype association with ACS.
ACS Binding (association) of associated with acute coronary syndrome
4) Confidence 0.18 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2267783 Disease Relevance 1.45 Pain Relevance 0.03
In neurons, activity dependent cAMP synthesis is primarily mediated by membrane bound Ca2+/calmodulin-stimulated adenylyl cyclases (ACs).
ACs Binding (bound) of in neurons
5) Confidence 0.14 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395303 Disease Relevance 0.19 Pain Relevance 0.29
Indeed, a few platelet-activation markers have been associated with ACS.
ACS Binding (associated) of in platelet associated with acute coronary syndrome
6) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954807 Disease Relevance 1.30 Pain Relevance 0.08
We focused our efforts on NSTE-ACS, which is generally associated with white, platelet-rich, and only partially occlusive thrombus, which cause minimal myocardial necrosis [1].
NSTE-ACS Binding (associated) of in platelet associated with necrosis, acute coronary syndrome and thrombosis
7) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954807 Disease Relevance 1.10 Pain Relevance 0.07
Moreover, there is no doubt platelets play a fundamental role in the thrombus formation that follows the atheroma plaque rupture and leads to an ACS.
ACS Binding (leads) of in plaque associated with acute coronary syndrome, atherosclerotic plaque, rupture and thrombosis
8) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954807 Disease Relevance 1.30 Pain Relevance 0.08
The objective was to identify, through a global proteomic approach, differentially regulated platelet proteins that could provide information on the molecular mechanisms playing a major role in the unwanted platelet activation associated with the ACS.


ACS Binding (associated) of in platelet associated with acute coronary syndrome
9) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954807 Disease Relevance 0.98 Pain Relevance 0.13

General Comments

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