INT190783

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Context Info
Confidence 0.35
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.35
Pain Relevance 2.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Adcy1) plasma membrane (Adcy1) nucleus (Adcy1)
Anatomy Link Frequency
nerve 1
neurons 1
Adcy1 (Mus musculus)
Pain Link Frequency Relevance Heat
Anterior cingulate cortex 75 98.72 Very High Very High Very High
Pain 53 96.12 Very High Very High Very High
Inflammation 25 95.64 Very High Very High Very High
Serotonin 66 95.32 Very High Very High Very High
Spinal cord 35 92.84 High High
Lasting pain 17 91.28 High High
Eae 16 89.48 High High
Neuropathic pain 11 76.32 Quite High
amygdala 23 72.24 Quite High
dorsal root ganglion 3 66.24 Quite High
Disease Link Frequency Relevance Heat
Myalgia 29 96.12 Very High Very High Very High
INFLAMMATION 25 95.64 Very High Very High Very High
Pain 41 91.28 High High
Inflammatory Pain 24 89.48 High High
Neuropathic Pain 45 76.32 Quite High
Targeted Disruption 46 72.28 Quite High
Nociception 13 71.44 Quite High
Ganglion Cysts 9 65.28 Quite High
Injury 4 37.36 Quite Low
Aids-related Complex 1 19.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In neurons, activity dependent cAMP synthesis is primarily mediated by membrane bound Ca2+/calmodulin-stimulated adenylyl cyclases (ACs).
adenylyl cyclase Binding (bound) of in neurons
1) Confidence 0.35 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395303 Disease Relevance 0.19 Pain Relevance 0.29
AC1 thus may contribute both presynaptically and postsynaptically to nerve ligation-induced plastic changes in the ACC.
AC1 Binding (ligation) of in nerve associated with anterior cingulate cortex
2) Confidence 0.30 Published 2009 Journal Mol Pain Section Body Doc Link PMC2639542 Disease Relevance 1.16 Pain Relevance 1.22
The 5HT1B receptor is negatively coupled to the adenylate cyclase 1 (AC1) through G-proteins of the G?
adenylate cyclase 1 Binding (coupled) of
3) Confidence 0.21 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0.25
The 5HT1B receptor is negatively coupled to the adenylate cyclase 1 (AC1) through G-proteins of the G?
AC1 Binding (coupled) of
4) Confidence 0.21 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0.27

General Comments

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