INT190788

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Context Info
Confidence 0.23
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.77
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Adcy8, Adcy1) plasma membrane (Adcy1) nucleus (Adcy1)
Anatomy Link Frequency
spinal cord 1
Adcy8 (Mus musculus)
Adcy1 (Mus musculus)
Pain Link Frequency Relevance Heat
Anterior cingulate cortex 21 99.44 Very High Very High Very High
Spinal cord 12 99.12 Very High Very High Very High
Pain 35 95.48 Very High Very High Very High
IPN 9 87.40 High High
allodynia 28 71.24 Quite High
Calcium channel 2 69.68 Quite High
Lasting pain 4 55.72 Quite High
carrageenan induced 1 32.68 Quite Low
Inflammation 18 31.48 Quite Low
intrathecal 3 27.12 Quite Low
Disease Link Frequency Relevance Heat
Myalgia 29 95.48 Very High Very High Very High
Nociception 11 92.84 High High
Inflammatory Pain 9 87.40 High High
Neuropathic Pain 29 71.24 Quite High
Pain 10 55.72 Quite High
Targeted Disruption 45 43.76 Quite Low
Congenital Anomalies 1 38.40 Quite Low
INFLAMMATION 18 31.48 Quite Low
Body Weight 5 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, in animals with genetic deletion of AC1 and AC8, forskolin may rescue behavioral phenotypes by activating non-Ca2+/calmodulin-stimulated adenylyl cyclases in both the ACC and spinal cord.
AC8 Positive_regulation (activating) of adenylyl cyclase in spinal cord associated with anterior cingulate cortex and spinal cord
1) Confidence 0.23 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395303 Disease Relevance 0.77 Pain Relevance 0.77

General Comments

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