INT190833

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Context Info
Confidence 0.53
First Reported 2006
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 6.61
Pain Relevance 4.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNA1) transmembrane transport (KCNA1)
Anatomy Link Frequency
adrenal gland 2
plasmas 1
autonomic 1
oocytes 1
KCNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
electroacupuncture 353 100.00 Very High Very High Very High
potassium channel 344 100.00 Very High Very High Very High
Acupuncture 146 100.00 Very High Very High Very High
Inflammation 83 97.36 Very High Very High Very High
Neuropathic pain 10 97.08 Very High Very High Very High
antagonist 15 91.68 High High
insula 8 84.52 Quite High
fibrosis 1 81.72 Quite High
Pain 68 81.20 Quite High
Hyperalgesia 42 79.52 Quite High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 55 99.64 Very High Very High Very High
Isaacs Syndrome 100 98.16 Very High Very High Very High
INFLAMMATION 93 97.36 Very High Very High Very High
Neuropathic Pain 10 97.08 Very High Very High Very High
Limbic Encephalitis 108 95.00 High High
Targeted Disruption 10 90.56 High High
Cancer 83 90.16 High High
Sleep Disorders 32 88.48 High High
Respiratory Disease 11 86.64 High High
Syndrome 177 85.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We tested whether the missense mutation alters human Kv1.1 channel function by expressing Kv1.1-T226K in Xenopus oocytes.
Spec (whether) Regulation (alters) of Kv1 in oocytes
1) Confidence 0.53 Published 2006 Journal Neurogenetics Section Body Doc Link PMC1820748 Disease Relevance 0.06 Pain Relevance 0
The stimulation by different acupuncturists may vary greatly, so the manipulation of needling is sometimes performed by electro-stimulation or electro-acupuncture (EA), in which the stimulation intensity can be regulated accurately by the current output and frequency, especially for acupuncture experiments.
Regulation (regulated) of EA associated with acupuncture
2) Confidence 0.26 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1397865 Disease Relevance 1.18 Pain Relevance 0.62
Our main aim was to investigate the specificity of the VGKC-antibodies for the different Kv1 subtypes and to relate these to the clinical phenotypes.
Spec (investigate) Regulation (specificity) of Kv1 associated with potassium channel
3) Confidence 0.10 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.60 Pain Relevance 0.18
It is likely that binding of Caspr2 antibodies results in down-regulation of Caspr2/Kv1.1/1.2 complexes on the peripheral nerve axon, leading to neuromyotonia, neuropathic pain and autonomic dysfunction.
Regulation (regulation) of Kv1 in autonomic associated with isaacs syndrome and neuropathic pain
4) Confidence 0.10 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.86 Pain Relevance 0.13
The effects of patient plasmas on Kv1 currents were determined after acute application, or after incubation for 24 or 72h.


Regulation (effects) of Kv1 in plasmas
5) Confidence 0.08 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0 Pain Relevance 0.05
We speculate that our results may indicate that functional connectivity in genuine and sham EA are differentially modulated by expectancy levels, however further research is needed to fully understand the sources of observed functional connectivity in this study.
Regulation (modulated) of EA associated with electroacupuncture
6) Confidence 0.04 Published 2010 Journal Mol Pain Section Body Doc Link PMC2993660 Disease Relevance 0.77 Pain Relevance 0.94
The targets for sera with lower VGKC antibodies should now be re-explored, but from our initial findings (unpublished observations) we anticipate that Kv1s, Caspr2 and contactin-2 will individually, or in combinations, prove to be targets in many patients with VGKC-antibody positive neuromyotonia, and also may be positive in some that are currently negative for VGKC-antibodies.
Regulation (targets) of Kv1s associated with isaacs syndrome and potassium channel
7) Confidence 0.03 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 1.20 Pain Relevance 0.32
To explore possible targets of EA in the Wnt/?
Spec (possible) Regulation (targets) of EA
8) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.07 Pain Relevance 0.21
Experiment 2 studied the effects of the adrenal gland on the therapeutic actions of EA using adrenalectomy (ADX) rats.
Regulation (effects) of EA in adrenal gland associated with electroacupuncture
9) Confidence 0.00 Published 2007 Journal BMC Complement Altern Med Section Abstract Doc Link PMC1976320 Disease Relevance 0.81 Pain Relevance 0.79
In Experiment 2 adrenalectomy (ADX) rats were used to study the effects of the adrenal gland on the therapeutic actions of EA.
Regulation (effects) of EA in adrenal gland associated with electroacupuncture
10) Confidence 0.00 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1976320 Disease Relevance 0.54 Pain Relevance 0.77
We previously reported that EA significantly inhibits edema compared to sham EA control in CFA-injected rats [9].
Regulation (control) of EA associated with pressure and volume under development and electroacupuncture
11) Confidence 0.00 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1976320 Disease Relevance 0.51 Pain Relevance 0.65

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