INT190844

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Context Info
Confidence 0.80
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.54
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Stxbp1) mitochondrion (Stxbp1) vesicle-mediated transport (Stxbp1)
plasma membrane (Stxbp1) protein complex (Stxbp1) cytoplasm (Stxbp1)
Anatomy Link Frequency
neuronal 1
neurons 1
Stxbp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 164 100.00 Very High Very High Very High
Neurotransmitter 12 83.44 Quite High
long-term potentiation 16 78.88 Quite High
agonist 4 62.00 Quite High
Central nervous system 14 46.64 Quite Low
Neurobehavioral 12 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
nMDA receptor 6 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Virus Diseases 188 99.74 Very High Very High Very High
Infection 40 98.96 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 91.76 High High
Borna Disease 10 50.00 Quite Low
Viral Infection 4 32.00 Quite Low
Disease 10 5.00 Very Low Very Low Very Low
Cognitive Disorder 6 5.00 Very Low Very Low Very Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low
Sprains And Strains 6 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rather, BDV blocked the phosphorylation of PKC neuronal substrates, such as MARCKS and Munc18, which play essential roles in vesicular cycling.
Phosphorylation (phosphorylation) of Munc18 in neuronal associated with virus diseases and kinase c
1) Confidence 0.80 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.83 Pain Relevance 0.69
We showed by Western blot analysis that the phosphorylation of MARCKS and Munc18–1/nSec1 (Munc18), two PKC substrates that have been implicated in the regulation of vesicular recycling [31,35], was impaired in BDV-infected neurons following direct stimulation of PKC by PMA (Figure 6A and 6B).


Phosphorylation (phosphorylation) of Munc18 in neurons associated with virus diseases and kinase c
2) Confidence 0.27 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.71 Pain Relevance 0.60

General Comments

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