INT190858

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Context Info
Confidence 0.33
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 10
Disease Relevance 6.29
Pain Relevance 3.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Marcks) cytoplasm (Marcks)
Anatomy Link Frequency
neurons 3
neuronal 1
band 1
Marcks (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 820 100.00 Very High Very High Very High
Neurotransmitter 60 94.92 High High
long-term potentiation 80 92.64 High High
nMDA receptor 30 87.56 High High
agonist 20 62.00 Quite High
Central nervous system 70 59.28 Quite High
Neurobehavioral 60 56.28 Quite High
tetrodotoxin 10 52.16 Quite High
Inflammation 30 5.00 Very Low Very Low Very Low
Glutamate 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Virus Diseases 940 99.74 Very High Very High Very High
Infection 200 98.96 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 20 91.76 High High
Sprains And Strains 30 65.00 Quite High
Cognitive Disorder 30 56.84 Quite High
Borna Disease 50 50.00 Quite Low
Disease 50 47.68 Quite Low
Neurodegenerative Disease 20 46.56 Quite Low
Targeted Disruption 20 39.64 Quite Low
Viral Infection 20 32.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, the phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS), a major PKC substrate in neurons [31], was severely impaired in BDV-infected neurons following treatment with glycine (Figure 4D).
Phosphorylation (phosphorylation) of MARCKS in neurons associated with virus diseases and kinase c
1) Confidence 0.33 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.83 Pain Relevance 0.20
Transfection experiments using increasing quantities of P plasmid showed that this inhibitory effect on the phosphorylation of MARCKS was dose dependent (Figure 8B and 8C).
Phosphorylation (phosphorylation) of MARCKS
2) Confidence 0.33 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.76 Pain Relevance 0.27
The phosphorylation of MARCKS was also impaired in BDV-infected neurons following exposure to high K+ pulses, although we observed a higher variability between experiments, likely due to the stronger effects of this stimulation procedure compared to glycine (unpublished data).
Phosphorylation (phosphorylation) of MARCKS in neurons associated with virus diseases
3) Confidence 0.33 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.72 Pain Relevance 0.20
Expression of P was sufficient to decrease significantly the phosphorylation of MARCKS after stimulation with PMA, whereas N or GFP had no effect (Figure 8A).
Phosphorylation (phosphorylation) of MARCKS
4) Confidence 0.33 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.78 Pain Relevance 0.37
The phosphorylation of MARCKS by PKC is implicated in actin-dependent cytoskeletal plasticity [41] and has been associated with PKC-mediated enhancement of neurotransmitter release, as well as with persistence of LTP in vivo [42].
Phosphorylation (phosphorylation) of MARCKS associated with neurotransmitter, kinase c and long-term potentiation
5) Confidence 0.33 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.79 Pain Relevance 0.72
Quantification of protein phosphorylation was carried out by measuring the density of the band corresponding to the phosphorylated protein normalized by the expression of the unphosphorylated protein, except for MARCKS phosphorylation which was normalized by ?
Phosphorylation (phosphorylation) of MARCKS in band
6) Confidence 0.33 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.08 Pain Relevance 0.08
Rather, BDV blocked the phosphorylation of PKC neuronal substrates, such as MARCKS and Munc18, which play essential roles in vesicular cycling.
Phosphorylation (phosphorylation) of MARCKS in neuronal associated with virus diseases and kinase c
7) Confidence 0.32 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.83 Pain Relevance 0.69
We showed by Western blot analysis that the phosphorylation of MARCKS and Munc18–1/nSec1 (Munc18), two PKC substrates that have been implicated in the regulation of vesicular recycling [31,35], was impaired in BDV-infected neurons following direct stimulation of PKC by PMA (Figure 6A and 6B).


Phosphorylation (phosphorylation) of MARCKS in neurons associated with virus diseases and kinase c
8) Confidence 0.25 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.71 Pain Relevance 0.60
(clone MC5, sc-80; Santa Cruz Biotechnology, Santa Cruz, California, United States); rabbit polyclonals to the cytoplasmic domain of synaptotagmin I (Total-Syt; Synaptic Systems), phospho-MARCKS (Ser152/156, a site specifically phosphorylated by PKC; Cell Signaling Technology, Danvers, Massachusetts, United States), MARCKS (Chemicon), PKC?
Phosphorylation (phosphorylated) of phospho-MARCKS associated with kinase c
9) Confidence 0.22 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.43 Pain Relevance 0.33
(clone MC5, sc-80; Santa Cruz Biotechnology, Santa Cruz, California, United States); rabbit polyclonals to the cytoplasmic domain of synaptotagmin I (Total-Syt; Synaptic Systems), phospho-MARCKS (Ser152/156, a site specifically phosphorylated by PKC; Cell Signaling Technology, Danvers, Massachusetts, United States), MARCKS (Chemicon), PKC?
Phosphorylation (phosphorylated) of MARCKS associated with kinase c
10) Confidence 0.22 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.37 Pain Relevance 0.39

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