INT19086

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.38
First Reported 1990
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 32
Total Number 32
Disease Relevance 16.77
Pain Relevance 5.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL1A1) extracellular region (COL1A1) cytoplasm (COL1A1)
Anatomy Link Frequency
TMJ 4
osteoblast 3
foot 2
ankle 2
PSC 1
COL1A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
reflex sympathetic dystrophy 51 100.00 Very High Very High Very High
Rsd 10 100.00 Very High Very High Very High
Snapping jaw 26 98.38 Very High Very High Very High
Cannabinoid receptor 36 98.36 Very High Very High Very High
cytokine 31 97.42 Very High Very High Very High
Pain 51 95.40 Very High Very High Very High
anesthesia 2 95.20 Very High Very High Very High
Chronic pancreatitis 70 95.12 Very High Very High Very High
Causalgia 4 92.88 High High
Cannabinoid 52 92.72 High High
Disease Link Frequency Relevance Heat
Complex Regional Pain Syndromes 72 100.00 Very High Very High Very High
Hypercalcemia 58 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 17 100.00 Very High Very High Very High
Reflex Sympathetic Dystrophy 5 100.00 Very High Very High Very High
Syndrome 3 100.00 Very High Very High Very High
Mucopolysaccharidoses 2 100.00 Very High Very High Very High
Metastasis 50 99.64 Very High Very High Very High
Primary Sclerosing Cholangitis 88 99.14 Very High Very High Very High
Osteoporosis 184 98.84 Very High Very High Very High
Temporomandibular Joint Syndrome 26 98.38 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical staining of HUCM constructs after 4 weeks revealed a strong presence of collagen I and minute amounts of collagen II, whereas TMJ constructs revealed little collagen I and no collagen II.
Negative_regulation (presence) of collagen I in TMJ associated with snapping jaw
1) Confidence 0.38 Published 2007 Journal Tissue Eng. Section Abstract Doc Link 17518722 Disease Relevance 0.85 Pain Relevance 0.85
We proposed to assess the effectiveness of vitamin C in prevention of CRPS I in foot and ankle surgery.
Negative_regulation (prevention) of CRPS I in ankle associated with complex regional pain syndromes
2) Confidence 0.38 Published 2009 Journal Foot Ankle Surg Section Abstract Doc Link 19840748 Disease Relevance 0.46 Pain Relevance 0.17
CONCLUSION: Vitamin C has been shown to be effective in preventing CRPS I secondary to wrist fracture, but few data are available with respect to foot and ankle cases.
Negative_regulation (preventing) of CRPS I in wrist
3) Confidence 0.38 Published 2009 Journal Foot Ankle Surg Section Body Doc Link 19840748 Disease Relevance 0.06 Pain Relevance 0
After 2 yr of treatment, risedronate decreased serum levels of the bone resorption marker collagen type I N-telopeptide by 35% compared with a 6% reduction with placebo (p = 0.003).
Negative_regulation (decreased) of collagen type I N-telopeptide associated with hypercalcemia
4) Confidence 0.36 Published 2009 Journal J. Bone Miner. Res. Section Abstract Doc Link 19257821 Disease Relevance 0.59 Pain Relevance 0
Interestingly, NFAT5 seems to be crucially involved in this differential regulation upon hypertonic challenge: it positively regulates collagen type II, while suppressing collagen type I (Figure 5b).
Negative_regulation (suppressing) of collagen type I
5) Confidence 0.36 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.32 Pain Relevance 0.07
The hypothesis of this study is that TMJ discs and serum of patients with closed lock will contain an increased amount of fibronectin and decreased amount of collagen I.
Negative_regulation (decreased) of collagen I in TMJ associated with snapping jaw
6) Confidence 0.32 Published 2009 Journal J. Oral Maxillofac. Surg. Section Abstract Doc Link 19070755 Disease Relevance 0.74 Pain Relevance 0.54
Correspondingly, COL2 protein levels increased under these conditions (4.8-fold in P1 cells and 2.9-fold in P2 cells), while the amount of COL1 diminished (by 4.7-fold in P1 cells and fivefold in P2 cells) (Figure 3e, f).


Negative_regulation (diminished) of COL1
7) Confidence 0.30 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.22 Pain Relevance 0.11
The present study demonstrates the effectiveness of vitamin C in preventing CRPS I of the foot and ankle-a frequent complication in our control group (9.6%).
Negative_regulation (preventing) of CRPS I in foot
8) Confidence 0.27 Published 2009 Journal Foot Ankle Surg Section Body Doc Link 19840748 Disease Relevance 0.05 Pain Relevance 0
Physiological tonicity improved expression of chondrogenic markers and NFAT5 and its target genes, while suppressing dedifferentiation marker collagen type I and improving type II/type I expression ratios >100-fold.
Negative_regulation (suppressing) of collagen type I
9) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2911888 Disease Relevance 0.18 Pain Relevance 0.03
The inhibition of osteoblast maturation by the glucocorticoid was found both in osteoblast precursors (reduced osteopontin) and in more mature osteoblasts (reduced collagen type I).
Negative_regulation (reduced) of collagen type I in osteoblast associated with osteoporosis
10) Confidence 0.26 Published 2010 Journal European Journal of Haematology Section Body Doc Link PMC2970902 Disease Relevance 0.92 Pain Relevance 0.05
In the infarcted zone, the extracellular myocardial matrix is modified; collagen type I decreases from 80% to 40%.
Negative_regulation (decreases) of collagen type I
11) Confidence 0.22 Published 2011 Journal Cardiology Research and Practice Section Body Doc Link PMC3021848 Disease Relevance 0.18 Pain Relevance 0.03
Levels of serum alkaline phosphatase and urinary collagen type I N-telopeptide were elevated at baseline and decreased continuously during the first 3 yr of therapy.
Negative_regulation (decreased) of collagen type I N-telopeptide
12) Confidence 0.21 Published 2003 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 14557424 Disease Relevance 0.48 Pain Relevance 0.08
However, in more mature osteoblast-like cells, we found that treatment with glucocorticoid induced a less mature phenotype as shown by suppression of the differentiation marker collagen type I (Fig. 4G).
Negative_regulation (suppression) of collagen type I in osteoblast associated with osteoporosis
13) Confidence 0.19 Published 2010 Journal European Journal of Haematology Section Body Doc Link PMC2970902 Disease Relevance 0.70 Pain Relevance 0
This is probably reflected in the clinical study by a significant drop in PINP levels, indicating the loss of osteoblast maturity and capacity to form the organic bone matrix by deposition of collagen type I.
Negative_regulation (deposition) of collagen type I in osteoblast associated with osteoporosis
14) Confidence 0.19 Published 2010 Journal European Journal of Haematology Section Body Doc Link PMC2970902 Disease Relevance 0.96 Pain Relevance 0
Significant decreases in both type 1 collagen N-telopeptide and osteocalcin are evident in women treated with antiresorptive agents as early as 3 months while the percent change of N-telopeptide at 3 months has been shown to correlate with change of spinal BMD at 12 months of treatment (Kim et al 2005).


Negative_regulation (decreases) of type 1 collagen N-telopeptide in spinal
15) Confidence 0.16 Published 2006 Journal Clinical Interventions in Aging Section Body Doc Link PMC2699644 Disease Relevance 0.46 Pain Relevance 0
DISCUSSION: This study suggests the rs1048101 single nucleotide polymorphism within the alpha1a-adrenoceptor as one risk factor for the development of CRPS I after the distal radius fracture.


Negative_regulation (development) of CRPS I in radius
16) Confidence 0.15 Published 2010 Journal Clin J Pain Section Body Doc Link 20173430 Disease Relevance 0.12 Pain Relevance 0
We proposed to assess the effectiveness of vitamin C in prevention of CRPS I in foot and ankle surgery.
Negative_regulation (prevention) of CRPS I in foot associated with complex regional pain syndromes
17) Confidence 0.13 Published 2009 Journal Foot Ankle Surg Section Abstract Doc Link 19840748 Disease Relevance 0.46 Pain Relevance 0.17
These data indicate that TMJ disc cells undergo significant changes due to monolayer expansion, experiencing losses in major chondrocytic markers (aggrecan and collagen type II) and fibroblastic markers (collagen type I) and posing a serious impediment to studies in which cell passaging is required.
Negative_regulation (losses) of collagen type I in TMJ associated with snapping jaw
18) Confidence 0.10 Published 2007 Journal Tissue Eng. Section Abstract Doc Link 17518584 Disease Relevance 0.23 Pain Relevance 0.23
The present study demonstrates the effectiveness of vitamin C in preventing CRPS I of the foot and ankle-a frequent complication in our control group (9.6%).
Negative_regulation (preventing) of CRPS I in ankle
19) Confidence 0.09 Published 2009 Journal Foot Ankle Surg Section Body Doc Link 19840748 Disease Relevance 0.05 Pain Relevance 0
Effects of PPS on proteoglycan, collagen type I and collagen type II deposition by MPCs in 5-day, 7-day and 10-day pellet cultures
Negative_regulation (deposition) of collagen type I
20) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox