INT190863

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Context Info
Confidence 0.23
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 4.71
Pain Relevance 2.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Marcks) cytoplasm (Marcks)
Anatomy Link Frequency
neurons 6
neuronal 2
Marcks (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 492 100.00 Very High Very High Very High
Neurotransmitter 36 82.56 Quite High
long-term potentiation 48 78.00 Quite High
agonist 12 62.48 Quite High
nMDA receptor 18 48.88 Quite Low
Central nervous system 42 45.76 Quite Low
Neurobehavioral 36 5.00 Very Low Very Low Very Low
Inflammation 18 5.00 Very Low Very Low Very Low
Glutamate 12 5.00 Very Low Very Low Very Low
Hippocampus 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Virus Diseases 564 99.98 Very High Very High Very High
Infection 120 99.44 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 12 92.24 High High
Borna Disease 30 50.00 Quite Low
Viral Infection 12 32.48 Quite Low
Disease 30 5.00 Very Low Very Low Very Low
Cognitive Disorder 18 5.00 Very Low Very Low Very Low
INFLAMMATION 18 5.00 Very Low Very Low Very Low
Sprains And Strains 18 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of P was sufficient to decrease significantly the phosphorylation of MARCKS after stimulation with PMA, whereas N or GFP had no effect (Figure 8A).
Negative_regulation (decrease) of Phosphorylation (phosphorylation) of MARCKS
1) Confidence 0.23 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.79 Pain Relevance 0.40
The phosphorylation of MARCKS was also impaired in BDV-infected neurons following exposure to high K+ pulses, although we observed a higher variability between experiments, likely due to the stronger effects of this stimulation procedure compared to glycine (unpublished data).
Negative_regulation (impaired) of Phosphorylation (phosphorylation) of MARCKS in neurons associated with virus diseases
2) Confidence 0.23 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.72 Pain Relevance 0.21
We showed by Western blot analysis that the phosphorylation of MARCKS and Munc18–1/nSec1 (Munc18), two PKC substrates that have been implicated in the regulation of vesicular recycling [31,35], was impaired in BDV-infected neurons following direct stimulation of PKC by PMA (Figure 6A and 6B).


Negative_regulation (impaired) of Phosphorylation (phosphorylation) of MARCKS in neurons associated with virus diseases and kinase c
3) Confidence 0.17 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.76 Pain Relevance 0.67
Transfection experiments using increasing quantities of P plasmid showed that this inhibitory effect on the phosphorylation of MARCKS was dose dependent (Figure 8B and 8C).
Negative_regulation (effect) of Phosphorylation (phosphorylation) of MARCKS
4) Confidence 0.17 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.76 Pain Relevance 0.29
In contrast, the phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS), a major PKC substrate in neurons [31], was severely impaired in BDV-infected neurons following treatment with glycine (Figure 4D).
Negative_regulation (impaired) of Phosphorylation (phosphorylation) of MARCKS in neurons associated with virus diseases and kinase c
5) Confidence 0.17 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.85 Pain Relevance 0.21
Rather, BDV blocked the phosphorylation of PKC neuronal substrates, such as MARCKS and Munc18, which play essential roles in vesicular cycling.
Negative_regulation (blocked) of Phosphorylation (phosphorylation) of MARCKS in neuronal associated with virus diseases and kinase c
6) Confidence 0.17 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.83 Pain Relevance 0.69

General Comments

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