INT190865

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Context Info
Confidence 0.20
First Reported 2006
Last Reported 2006
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.79
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Marcks) cytoplasm (Marcks)
Anatomy Link Frequency
band 4
Marcks (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 328 100.00 Very High Very High Very High
Neurotransmitter 24 95.76 Very High Very High Very High
long-term potentiation 32 93.48 High High
agonist 8 57.04 Quite High
Central nervous system 28 54.72 Quite High
Neurobehavioral 24 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
nMDA receptor 12 5.00 Very Low Very Low Very Low
Glutamate 8 5.00 Very Low Very Low Very Low
Hippocampus 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Virus Diseases 376 94.52 High High
Infection 80 94.00 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 8 86.80 High High
Borna Disease 20 50.00 Quite Low
Viral Infection 8 27.04 Quite Low
Epstein-barr Virus 4 24.88 Low Low
Disease 20 5.00 Very Low Very Low Very Low
Cognitive Disorder 12 5.00 Very Low Very Low Very Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Sprains And Strains 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quantification of protein phosphorylation was carried out by measuring the density of the band corresponding to the phosphorylated protein normalized by the expression of the unphosphorylated protein, except for MARCKS phosphorylation which was normalized by ?
Neg (except) Positive_regulation (measuring) of Phosphorylation (phosphorylation) of MARCKS in band
1) Confidence 0.20 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.13 Pain Relevance 0.09
The phosphorylation of MARCKS by PKC is implicated in actin-dependent cytoskeletal plasticity [41] and has been associated with PKC-mediated enhancement of neurotransmitter release, as well as with persistence of LTP in vivo [42].
Positive_regulation (implicated) of Phosphorylation (phosphorylation) of MARCKS associated with neurotransmitter, kinase c and long-term potentiation
2) Confidence 0.20 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.79 Pain Relevance 0.73
Quantification of protein phosphorylation was carried out by measuring the density of the band corresponding to the phosphorylated protein normalized by the expression of the unphosphorylated protein, except for MARCKS phosphorylation which was normalized by ?
Neg (except) Positive_regulation (except) of Phosphorylation (phosphorylation) of MARCKS in band
3) Confidence 0.20 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.08 Pain Relevance 0.09
Expression of P was sufficient to decrease significantly the phosphorylation of MARCKS after stimulation with PMA, whereas N or GFP had no effect (Figure 8A).
Positive_regulation (after) of Phosphorylation (phosphorylation) of MARCKS
4) Confidence 0.19 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.78 Pain Relevance 0.37

General Comments

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