INT190878

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Context Info
Confidence 0.29
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.76
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme regulator activity (Apoc3) lipid binding (Apoc3) transport (Apoc3)
extracellular space (Apoc3) extracellular region (Apoc3)
Apoc3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 27 99.36 Very High Very High Very High
agonist 3 98.44 Very High Very High Very High
alcohol 3 55.24 Quite High
psoriasis 63 50.00 Quite Low
ischemia 1 35.36 Quite Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
drug abuse 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 49 100.00 Very High Very High Very High
INFLAMMATION 34 99.36 Very High Very High Very High
Hyperlipidemia 18 99.24 Very High Very High Very High
Psoriasis 106 97.88 Very High Very High Very High
Atherosclerosis 42 94.08 High High
Atherosclerotic Plaque 4 93.72 High High
Cardiovascular Disease 25 92.80 High High
Disease 21 84.56 Quite High
Metabolic Syndrome 3 82.76 Quite High
Nicotine Addiction 2 76.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In most studies, elevated levels of apoA1, apoB [16, 43], apoC3, and apoE [41, 76–78] were detected in the serum of psoriatic patients compared to the healthy control group.
Positive_regulation (elevated) of Gene_expression (levels) of apoC3 associated with psoriasis
1) Confidence 0.29 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 1.09 Pain Relevance 0.03
However, it will be necessary to develop compounds with dissociated activities, since a full agonist, while potentially exerting anti-inflammatory activities, may be expected to induce apoC-III expression and increase TG concentration.
Positive_regulation (induce) of Gene_expression (expression) of apoC-III associated with inflammation and agonist
2) Confidence 0.19 Published 2003 Journal Nuclear Receptor Signaling Section Body Doc Link PMC1402228 Disease Relevance 0.69 Pain Relevance 0.27
-/- mice exhibit a dyslipidemic phenotype with increased very low-density lipoprotein (VLDL) triglyceride levels and apolipoprotein CIII (apoCIII) expression that participates in regulating lipoprotein lipase activity and triglyceride levels [12,13].
Positive_regulation (increased) of Gene_expression (expression) of apoCIII associated with disorder of lipid metabolism
3) Confidence 0.10 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2807425 Disease Relevance 0.98 Pain Relevance 0

General Comments

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