INT190880

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Context Info
Confidence 0.27
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 2.24
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ncor2) DNA binding (Ncor2)
Anatomy Link Frequency
thyroid 1
Ncor2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 208 91.44 High High
addiction 4 81.28 Quite High
tolerance 18 78.52 Quite High
Inflammation 400 76.28 Quite High
metalloproteinase 4 71.00 Quite High
chemokine 23 70.20 Quite High
cytokine 99 69.72 Quite High
Inflammatory response 37 62.04 Quite High
Inflammatory mediators 16 40.08 Quite Low
Central nervous system 44 33.44 Quite Low
Disease Link Frequency Relevance Heat
Repression 22 95.92 Very High Very High Very High
Diabetes Mellitus 14 93.56 High High
Insulin Resistance 18 93.16 High High
Obesity 62 83.08 Quite High
Disease 49 80.20 Quite High
Impaired Glucose Tolerance 18 78.52 Quite High
INFLAMMATION 474 76.28 Quite High
Cancer 357 50.00 Quite Low
Hypolipidemia 4 50.00 Quite Low
Targeted Disruption 45 49.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
molecules, which bind to NCoR and prevent its clearance from the promoter.
NCoR Binding (bind) of
1) Confidence 0.27 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.19 Pain Relevance 0.13
interacts with corepressors NCoR and SMRT, but the importance of this interaction for PPAR?
SMRT Binding (interacts) of
2) Confidence 0.23 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0 Pain Relevance 0
interacts with corepressors NCoR and SMRT, but the importance of this interaction for PPAR?
NCoR Binding (interacts) of
3) Confidence 0.23 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0 Pain Relevance 0
may interact with the nuclear co-repressors N-CoR and SMRT

[Harding et al., 1997].

SMRT Binding (interact) of
4) Confidence 0.16 Published 2003 Journal Nuclear Receptor Signaling Section Body Doc Link PMC1402228 Disease Relevance 0.08 Pain Relevance 0
may interact with the nuclear co-repressors N-CoR and SMRT

[Harding et al., 1997].

N-CoR Binding (interact) of
5) Confidence 0.16 Published 2003 Journal Nuclear Receptor Signaling Section Body Doc Link PMC1402228 Disease Relevance 0.08 Pain Relevance 0
, similar to ERs, is bound to corepressor proteins such as nuclear receptor corepressor (NCoR) or silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) [22].
NCoR Binding (bound) of in thyroid
6) Confidence 0.11 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.55 Pain Relevance 0.08
molecules, which bind to NCoR and prevent its clearance from the promoter, leading to a sustained repressed state [57].
NCoR Binding (bind) of
7) Confidence 0.10 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443396 Disease Relevance 0.33 Pain Relevance 0.27
The requirement for the NCoR corepressor complex explains why only a subset of LPS-inducible genes is
NCoR Binding (complex) of
8) Confidence 0.08 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443396 Disease Relevance 0.32 Pain Relevance 0.26
B activation, the NCoR complex is degraded by the proteasome, NF-?
NCoR Binding (complex) of
9) Confidence 0.08 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443396 Disease Relevance 0.43 Pain Relevance 0.34
Remarkably, also AP-1-mediated gene transcription depends on the loss of NCoR complexes, suggesting a similar mechanism of PPAR?
NCoR Binding (complexes) of
10) Confidence 0.08 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443396 Disease Relevance 0.26 Pain Relevance 0.14
binds the corepressor molecule NCoR which maintains
NCoR Binding (binds) of
11) Confidence 0.02 Published 2008 Journal PPAR Research Section Body Doc Link PMC2441778 Disease Relevance 0 Pain Relevance 0.04
transrepression involves sumoylation of receptor and association of NCoR [12].
NCoR Binding (association) of
12) Confidence 0.02 Published 2008 Journal PPAR Research Section Body Doc Link PMC2441778 Disease Relevance 0 Pain Relevance 0.08

General Comments

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