INT190881

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Context Info
Confidence 0.43
First Reported 2003
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.76
Pain Relevance 2.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rora) DNA binding (Rora)
Anatomy Link Frequency
neurons 2
spinal 1
Rora (Mus musculus)
Pain Link Frequency Relevance Heat
substantia gelatinosa 228 100.00 Very High Very High Very High
ischemia 1 99.40 Very High Very High Very High
GABAergic 52 99.04 Very High Very High Very High
Dorsal horn 44 96.52 Very High Very High Very High
Action potential 20 95.52 Very High Very High Very High
Glutamate 12 93.84 High High
gABA 48 93.40 High High
Spinal cord 72 93.28 High High
antagonist 32 93.28 High High
spinal dorsal horn 20 91.48 High High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 1 99.40 Very High Very High Very High
Nociception 28 97.68 Very High Very High Very High
Disorder Of Lipid Metabolism 3 82.20 Quite High
Hypolipidemia 1 81.32 Quite High
Atherosclerosis 9 80.16 Quite High
Pain 12 79.08 Quite High
Disease 3 72.52 Quite High
INFLAMMATION 19 72.24 Quite High
Targeted Disruption 16 67.12 Quite High
Anxiety Disorder 4 59.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ischemia-induced angiogenesis is also enhanced in staggerer mice

[Besnard et al., 2001] and expression of endothelial NO synthase (eNOS) protein is increased in ischemic tissues of staggerer mice [Besnard et al., 2001].


Positive_regulation (enhanced) of staggerer associated with ischemia
1) Confidence 0.43 Published 2003 Journal Nuclear Receptor Signaling Section Body Doc Link PMC1402228 Disease Relevance 0.77 Pain Relevance 0.09
The result suggests the tonic activation of GluR5 in the spinal SG.
Positive_regulation (activation) of SG in spinal associated with substantia gelatinosa
2) Confidence 0.07 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0.07 Pain Relevance 0.64
ATPA could also induce inward currents in all SG neurons recorded.
Positive_regulation (induce) of SG in neurons associated with substantia gelatinosa
3) Confidence 0.05 Published 2006 Journal Mol Pain Section Abstract Doc Link PMC1570342 Disease Relevance 0.06 Pain Relevance 0.55
Since activation of presynaptic GluR5 in the SG decreased the postsynaptic interneuronal excitability, the net effect may cause an increase in excitability, thereby enhancing the nociceptive transmission.
Positive_regulation (activation) of SG associated with nociception and substantia gelatinosa
4) Confidence 0.05 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0.86 Pain Relevance 0.77
Both GABAergic and glycinergic release were enhanced by GluR5 activation in SG neurons
Positive_regulation (activation) of SG in neurons associated with substantia gelatinosa and gabaergic
5) Confidence 0.05 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.67

General Comments

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