INT190882

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Context Info
Confidence 0.23
First Reported 2003
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.67
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoa1) extracellular space (Apoa1) extracellular region (Apoa1)
nucleus (Apoa1) enzyme binding (Apoa1)
Anatomy Link Frequency
bile 2
Apoa1 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 43 100.00 Very High Very High Very High
alcohol 14 99.18 Very High Very High Very High
agonist 36 94.36 High High
ischemia 3 77.72 Quite High
psoriasis 63 56.08 Quite High
Inflammation 54 51.12 Quite High
cytokine 7 20.96 Low Low
cINOD 9 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
Crohn's disease 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 330 100.00 Very High Very High Very High
Psoriasis 106 99.64 Very High Very High Very High
Targeted Disruption 30 96.68 Very High Very High Very High
Hyperlipidemia 10 88.12 High High
Cardiovascular Disease 33 83.60 Quite High
Cv Unclassified Under Development 2 77.72 Quite High
Repression 7 71.84 Quite High
Nicotine Addiction 13 65.04 Quite High
Apoptosis 42 62.44 Quite High
Myocardial Infarction 24 61.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Many authors did not show any differences in apoA1, apoA2, and apoB levels between psoriatic patients and the control group [10, 76, 80].
Neg (not) Regulation (differences) of Gene_expression (levels) of apoA1 associated with psoriasis
1) Confidence 0.23 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 1.23 Pain Relevance 0.03
Fibrates influence the ApoA-I gene expression,
Regulation (influence) of Gene_expression (expression) of ApoA-I gene
2) Confidence 0.12 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.19 Pain Relevance 0.05
Mechanisms by which alcohol consumption increases HDL-C may involve changes in Apo AI synthesis and transportation, inhibition of CETP activity and stimulation of early steps in RCT (Van der Gaag et al 2001).
Regulation (changes) of Gene_expression (synthesis) of Apo AI associated with disorder of lipid metabolism and alcohol
3) Confidence 0.12 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.06 Pain Relevance 0.24
However, the regulation of apoA-I gene expression and, as a consequence, HDL metabolism, appears to species-specific.
Spec (appears) Regulation (regulation) of Gene_expression (expression) of apoA-I gene associated with disorder of lipid metabolism
4) Confidence 0.10 Published 2003 Journal Nuclear Receptor Signaling Section Body Doc Link PMC1402228 Disease Relevance 0.66 Pain Relevance 0.06
Another study showed that the inhibitory effects of bile acids on HDL and ApoA-I levels were much more pronounced in SXR null mice, whereas these effects were blocked in transgenic humanized mice [Masson et al., 2005].
Regulation (effects) of Gene_expression (levels) of ApoA-I in bile associated with targeted disruption, bile and disorder of lipid metabolism
5) Confidence 0.09 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.54 Pain Relevance 0.05

General Comments

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