INT190883

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Context Info
Confidence 0.38
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 19
Disease Relevance 14.18
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme regulator activity (Apoc3) lipid binding (Apoc3) transport (Apoc3)
extracellular space (Apoc3) extracellular region (Apoc3)
Anatomy Link Frequency
macrophage 1
neuron 1
brains 1
astrocytes 1
body 1
Apoc3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 151 99.22 Very High Very High Very High
agonist 40 98.30 Very High Very High Very High
long-term potentiation 28 98.04 Very High Very High Very High
Inflammatory response 26 96.40 Very High Very High Very High
cytokine 72 95.68 Very High Very High Very High
Intracerebroventricular 2 87.80 High High
Thalamus 16 84.32 Quite High
anesthesia 4 81.52 Quite High
nMDA receptor 5 70.48 Quite High
ischemia 2 64.96 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 357 100.00 Very High Very High Very High
Targeted Disruption 385 99.88 Very High Very High Very High
Psoriasis 212 99.32 Very High Very High Very High
INFLAMMATION 194 99.22 Very High Very High Very High
Obesity 554 99.02 Very High Very High Very High
Hyperlipidemia 54 98.88 Very High Very High Very High
Body Weight 288 96.68 Very High Very High Very High
Atherosclerosis 92 94.08 High High
Cardiovascular Disease 99 92.92 High High
Dyslipidemia /

Combined Dyslipidemia

38 92.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In most studies, elevated levels of apoA1, apoB [16, 43], apoC3, and apoE [41, 76–78] were detected in the serum of psoriatic patients compared to the healthy control group.
Gene_expression (levels) of apoC3 associated with psoriasis
1) Confidence 0.38 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 1.09 Pain Relevance 0.03
In most studies, elevated levels of apoA1, apoB [16, 43], apoC3, and apoE [41, 76–78] were detected in the serum of psoriatic patients compared to the healthy control group.
Gene_expression (detected) of apoC3 associated with psoriasis
2) Confidence 0.38 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 1.04 Pain Relevance 0.03
However, it will be necessary to develop compounds with dissociated activities, since a full agonist, while potentially exerting anti-inflammatory activities, may be expected to induce apoC-III expression and increase TG concentration.
Gene_expression (expression) of apoC-III associated with inflammation and agonist
3) Confidence 0.24 Published 2003 Journal Nuclear Receptor Signaling Section Body Doc Link PMC1402228 Disease Relevance 0.69 Pain Relevance 0.27
positively regulates expression of the mouse and human apoC-III genes and in human HepG2 cells ROR-?
Gene_expression (expression) of apoC-III
4) Confidence 0.24 Published 2003 Journal Nuclear Receptor Signaling Section Body Doc Link PMC1402228 Disease Relevance 0.44 Pain Relevance 0.13
-/- mice exhibit a dyslipidemic phenotype with increased very low-density lipoprotein (VLDL) triglyceride levels and apolipoprotein CIII (apoCIII) expression that participates in regulating lipoprotein lipase activity and triglyceride levels [12,13].
Gene_expression (expression) of apoCIII associated with disorder of lipid metabolism
5) Confidence 0.12 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2807425 Disease Relevance 0.94 Pain Relevance 0
-/- mice exhibit a dyslipidemic phenotype with increased very low-density lipoprotein (VLDL) triglyceride levels and apolipoprotein CIII (apoCIII) expression that participates in regulating lipoprotein lipase activity and triglyceride levels [12,13].
Gene_expression (expression) of apolipoprotein CIII associated with disorder of lipid metabolism
6) Confidence 0.12 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2807425 Disease Relevance 0.95 Pain Relevance 0
expression, reduces the expression levels of apolipoprotein C-III (ApoC-III), a
Gene_expression (expression) of ApoC-III associated with disorder of lipid metabolism
7) Confidence 0.11 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.94 Pain Relevance 0.03
expression, reduces the expression levels of apolipoprotein C-III (ApoC-III), a
Gene_expression (expression) of C-III associated with disorder of lipid metabolism
8) Confidence 0.09 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.94 Pain Relevance 0.03
The molecular mechanisms underlying the effects of fenofibrate on obesity and lipid metabolism involve the changes in the expression of apolipoprotein C-III (apo C-III) and ACOX.
Gene_expression (expression) of C-III associated with obesity and disorder of lipid metabolism
9) Confidence 0.06 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 0.77 Pain Relevance 0
Thus, the effect of fenofibrate on the body weight of female Sham LDLR-null mice cannot be explained simply in terms of an altered and enhanced flux of FAs and triglycerides, since fenofibrate increased ACOX mRNA and decreased apo C-III gene expression in this group (although this expression was lower than in the OVX group).
Gene_expression (expression) of C-III in body associated with body weight
10) Confidence 0.06 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 0.93 Pain Relevance 0
The molecular mechanisms underlying the effects of fenofibrate on obesity and lipid metabolism involve the changes in the expression of apolipoprotein C-III (apo C-III) and ACOX.
Gene_expression (expression) of C-III associated with obesity and disorder of lipid metabolism
11) Confidence 0.06 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 0.77 Pain Relevance 0
-oxidation and apo C-III gene expression between female Sham and OVX mice.
Gene_expression (expression) of C-III
12) Confidence 0.06 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 0.98 Pain Relevance 0
Preparation of HDL released into conditioned media of astrocytes expressing apoE3 or apoE4
Gene_expression (expressing) of apoE3 in astrocytes associated with disorder of lipid metabolism
13) Confidence 0.02 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.10 Pain Relevance 0.05
Postnatal day 2 mice that possess the homozygous epsilon 3 (3/3) or epsilon 4 (4/4) allele, and correctly expressing human apoE3 or apoE4 proteins, respectively, were used in this study.


Gene_expression (expressing) of apoE3
14) Confidence 0.02 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.24 Pain Relevance 0.08
In various transgenic lines in which human ApoE3 or ApoE4 was expressed under a GFAP or a neuron-specific enolase (NSE) promoter, C-terminal fragments of ApoE4 (and to a lesser degree of ApoE3) accumulated, and tau protein appeared to be hyperphosphorylated only in the NSE-ApoE Tg mice [34].


Gene_expression (expressed) of ApoE3 in neuron associated with targeted disruption
15) Confidence 0.01 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.45 Pain Relevance 0.17
This effect was prevented by the expression of the ApoE3 allele [41].


Gene_expression (expression) of ApoE3
16) Confidence 0.01 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.44 Pain Relevance 0.09
ApoE-TR mice expressing the apoE3 isoform are identical to wild type mice in both LTP induction and spatial learning.
Gene_expression (expressing) of apoE3 associated with long-term potentiation
17) Confidence 0.01 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.29 Pain Relevance 0.16
The murine monocyte–macrophage cell line (RAW 264.7) stably transfected to produce equal amounts of human apoE3 or apoE4 was used.
Gene_expression (produce) of apoE3 in macrophage
18) Confidence 0.01 Published 2007 Journal Biochemical and Biophysical Research Communications Section Abstract Doc Link PMC2096715 Disease Relevance 0.96 Pain Relevance 0.21
By using transgenic mice expressing human apoE3 or apoE4, Lynch et al. [14] determined that apoE4 mice showed elevated systemic and brain pro-inflammatory cytokines following intravenous administration of LPS, and Ophir et al. [12] demonstrated that the expression of inflammation genes was higher and more prolongated in the brains of apoE4 following intracerebroventricular injection of LPS.
Gene_expression (expressing) of apoE3 in brains associated with targeted disruption, inflammation, intracerebroventricular and cytokine
19) Confidence 0.01 Published 2007 Journal Biochemical and Biophysical Research Communications Section Body Doc Link PMC2096715 Disease Relevance 1.03 Pain Relevance 0.63

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