INT190964

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Context Info
Confidence 0.29
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.29
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Scn2a1)
Anatomy Link Frequency
neurons 2
brain structures 2
Scn2a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Raphe 82 100.00 Very High Very High Very High
Spinal cord 6 100.00 Very High Very High Very High
Neurotransmitter 96 99.40 Very High Very High Very High
Glutamate 34 80.64 Quite High
cerebral cortex 3 16.36 Low Low
endometriosis 3 8.44 Low Low
gABA 33 5.00 Very Low Very Low Very Low
Neuropeptide 28 5.00 Very Low Very Low Very Low
Eae 23 5.00 Very Low Very Low Very Low
antagonist 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 5 100.00 Very High Very High Very High
Injury 10 99.16 Very High Very High Very High
Stroke 75 89.68 High High
Congenital Anomalies 5 88.28 High High
Sleep Disorders 115 72.48 Quite High
Cancer 16 56.68 Quite High
Ganglion Cysts 5 52.96 Quite High
Aging 31 52.72 Quite High
Targeted Disruption 17 46.24 Quite Low
Endometriosis (extended) 7 36.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to the SCN, PVN and IML are important brain structures controlling melatonin production.
Regulation (controlling) of Gene_expression (production) of SCN in brain structures associated with spinal cord
1) Confidence 0.29 Published 2008 Journal J Circadian Rhythms Section Body Doc Link PMC2584098 Disease Relevance 0.93 Pain Relevance 0.31
It is observed that the presence of neurotransmitters in the afferent and efferent projections of the SCN is equally important for the entrainment of the clock and for the control of overt rhythms.
Regulation (important) of Gene_expression (projections) of SCN associated with neurotransmitter
2) Confidence 0.28 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0.11 Pain Relevance 0.40
Thus, nearly 1/2 of little SAAS-positive neurons in the rat SCN are targets of the light signaling pathway, and ?
Regulation (positive) of Gene_expression (neurons) of SCN in neurons
3) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935382 Disease Relevance 0.05 Pain Relevance 0
Effect of a dark pulse on c-FOS-ir within the SCN, IGL, MRN and DRN structures
Regulation (Effect) of Gene_expression (structures) of SCN associated with raphe
4) Confidence 0.10 Published 2008 Journal Mol Brain Section Body Doc Link PMC2632999 Disease Relevance 0 Pain Relevance 0.19
Based on our present data, we predict that MRN-SCN projections are more important than IGL-SCN projections under these conditions.
Regulation (important) of Gene_expression (projections) of SCN associated with raphe
5) Confidence 0.10 Published 2008 Journal Mol Brain Section Body Doc Link PMC2632999 Disease Relevance 0.14 Pain Relevance 0.12
Age alters the 24-h expression profile of CLOCK and its binding partner BMAL1 in the hamster SCN, but there is no effect of age on the 24-h profile of either Per1 or Per2 proteins when hamsters are housed in constant darkness.
Regulation (alters) of Gene_expression (expression) of SCN
6) Confidence 0.03 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC2995617 Disease Relevance 0.05 Pain Relevance 0
Ovarian hormones also influence the expression of circadian clock genes both within and outside of the SCN.
Regulation (influence) of Gene_expression (expression) of SCN
7) Confidence 0.02 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2834958 Disease Relevance 0 Pain Relevance 0

General Comments

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