INT190983

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Context Info
Confidence 0.13
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.51
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Vip) nucleus (Per1) protein binding transcription factor activity (Per1)
cytoplasm (Per1) signal transducer activity (Per1)
Vip (Rattus norvegicus)
Per1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 44 96.80 Very High Very High Very High
Neurotransmitter 190 90.72 High High
depression 4 68.08 Quite High
tolerance 2 33.84 Quite Low
Neuropeptide 24 19.84 Low Low
gABA 60 5.00 Very Low Very Low Very Low
Somatostatin 34 5.00 Very Low Very Low Very Low
substance P 22 5.00 Very Low Very Low Very Low
Enkephalin 22 5.00 Very Low Very Low Very Low
agonist 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 14 88.96 High High
Chronic Disease 2 72.32 Quite High
Hypertension 18 70.32 Quite High
Diabetes Mellitus 4 69.20 Quite High
Depression 4 68.08 Quite High
Cancer 10 34.44 Quite Low
Lymphatic System Cancer 2 21.64 Low Low
Targeted Disruption 8 17.00 Low Low
Sleep Disorders 16 5.00 Very Low Very Low Very Low
Affective Disorder 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nielsen and co-workers [172] showed that VIP induces per1 and per2 gene expression in rat SCN in a phase dependent manner.
VIP Positive_regulation (induces) of Gene_expression (expression) of per1
1) Confidence 0.13 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0 Pain Relevance 0
Further, Nielsen and co-workers [172] also have shown that VIP induces per1 and per2 expression in a phase-dependent manner, thereby suggesting that VIP is important for the light-induced phase shift at night.


VIP Positive_regulation (induces) of Gene_expression (expression) of per1
2) Confidence 0.13 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0.51 Pain Relevance 0.27

General Comments

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