INT190988

Context Info Confidence 0.16 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.10 Pain Relevance 0.57

extracellular region (Vip) transmembrane transport (Scn2a1)

Anatomy Link Frequency dorsal 2 Vip (Rattus norvegicus) Scn2a1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat gABA 60 99.08 GABAergic 4 83.48 GABA receptor 6 73.28 Neurotransmitter 190 56.08 Neuropeptide 24 20.72 Glutamate 44 5.00 Somatostatin 34 5.00 substance P 22 5.00 Enkephalin 22 5.00 agonist 18 5.00

Disease Link Frequency Relevance Heat Generalized Anxiety Disorder 4 96.16 Affective Disorder 16 11.72 Hypertension 18 5.00 Sleep Disorders 16 5.00 Disease 14 5.00 Neuroleptic Malignant Syndrome 10 5.00 Cancer 10 5.00 Targeted Disruption 8 5.00 Ganglion Cysts 8 5.00 Depression 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Nielsen and co-workers [172] showed that VIP induces per1 and per2 gene expression in rat SCN in a phase dependent manner.

VIP Positive_regulation (induces) of Gene_expression (expression) of SCN

1) Confidence 0.16 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0 Pain Relevance 0

A circadian rhythm in GABA transmission in the dorsal part of the mouse SCN, with requirement of VIP for the expression of this rhythm, is reported by Itri and co-workers [155].

VIP Positive_regulation (requirement) of Gene_expression (expression) of SCN in dorsal associated with gaba

2) Confidence 0.13 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0.10 Pain Relevance 0.57

General Comments

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