INT190988

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Context Info
Confidence 0.16
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.10
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Vip) transmembrane transport (Scn2a1)
Anatomy Link Frequency
dorsal 2
Vip (Rattus norvegicus)
Scn2a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 60 99.08 Very High Very High Very High
GABAergic 4 83.48 Quite High
GABA receptor 6 73.28 Quite High
Neurotransmitter 190 56.08 Quite High
Neuropeptide 24 20.72 Low Low
Glutamate 44 5.00 Very Low Very Low Very Low
Somatostatin 34 5.00 Very Low Very Low Very Low
substance P 22 5.00 Very Low Very Low Very Low
Enkephalin 22 5.00 Very Low Very Low Very Low
agonist 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 4 96.16 Very High Very High Very High
Affective Disorder 16 11.72 Low Low
Hypertension 18 5.00 Very Low Very Low Very Low
Sleep Disorders 16 5.00 Very Low Very Low Very Low
Disease 14 5.00 Very Low Very Low Very Low
Neuroleptic Malignant Syndrome 10 5.00 Very Low Very Low Very Low
Cancer 10 5.00 Very Low Very Low Very Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low
Ganglion Cysts 8 5.00 Very Low Very Low Very Low
Depression 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nielsen and co-workers [172] showed that VIP induces per1 and per2 gene expression in rat SCN in a phase dependent manner.
VIP Positive_regulation (induces) of Gene_expression (expression) of SCN
1) Confidence 0.16 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0 Pain Relevance 0
A circadian rhythm in GABA transmission in the dorsal part of the mouse SCN, with requirement of VIP for the expression of this rhythm, is reported by Itri and co-workers [155].
VIP Positive_regulation (requirement) of Gene_expression (expression) of SCN in dorsal associated with gaba
2) Confidence 0.13 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0.10 Pain Relevance 0.57

General Comments

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